Art. -Nr.: HY-N5135

Liriopesides B

(Synonyms: Nolinospiroside F)

1 Cited Publications

Kundenbewertung

Based on 1 publication(s) in Google Scholar

Liriopesides B (Nolinospiroside F) is a steroidal saponin isolated from Ophiopogon japonicas. Liriopesides B has anti-oxidative and anti-aging effects.

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Reinheit: 99.92%
CAS. Nr.: 87425-34-1
Formel: C₃₉H₆₂O₁₂
Molecular Weight:722.90

Speicherung:

-20°C, sealed storage, away from moisture and light

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Liriopesides B Chemical Structure

CAS. Nr.: 87425-34-1

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Publications Citing Use of MedChemExpress (MCE) Liriopesides B

Transl Cancer Res. 2025 Oct 31;14(10):6637-6652. [Abstract]

Customer Validation & Images

Apoptosis AnalysisWBCell Proliferation/Viability AssayCell Migration/Invasion AssayIn Vivo Efficacy Study

Apoptosis Analysis
WB
Cell Proliferation/Viability Assay
Cell Migration/Invasion Assay
In Vivo Efficacy Study

Biologische Aktivität
- Beschreibung
- In Vitro
Chemical Information
Publications (1)
Lösungsmittel & Löslichkeit
- In Vitro
- In Vivo
Reinheit & Dokumentation
Verweise
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

Liriopesides B (Nolinospiroside F) is a steroidal saponin isolated from Ophiopogon japonicas. Liriopesides B has anti-oxidative and anti-aging effects^[1].

In Vitro

Liriopesides B (Nolinospiroside F) increases SIRT1 activity^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS. Nr. 87425-34-1
Appearance Solid
Molecular Weight 722.90
Formel C₃₉H₆₂O₁₂
Color White to light yellow
SMILES

O[C@H]([C@H]([C@H]([C@@H](C)O1)O)O)[C@@H]1O[C@@H]2C[C@H](O[C@H]3[C@@H]([C@@H]([C@H]([C@H](C)O3)O)O)O)CC4=CCC5C6C[C@@]7(O[C@@]8(OC[C@@H](C)CC8)[C@@H](C)[C@@]7([C@]6(CCC5[C@@]24C)C)[H])[H]
Synonyms

Nolinospiroside F
Structure Classification
- Steroids
Initial Source
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

-20°C, sealed storage, away from moisture and light

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Publications (1)

All Apoptosis AnalysisWBCell Proliferation/Viability AssayCell Migration/Invasion AssayIn Vivo Efficacy Study

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Journal Impact Factor

Transl Cancer Res

Liriopesides B inhibits proliferation and metastasis and induces apoptosis of oral squamous cell carcinoma via the PI3K/Akt/mTOR signaling pathway. [Abstract]

2025 Oct 31;14(10):6637-6652. PMID: 41234828

Liriopesides B purchased from MedChemExpress. Usage Cited in: Transl Cancer Res. 2025 Oct 31;14(10):6637-6652. [Abstract]

Liriopesides B (LPB) (12, 24 μM) induces apoptosis in SAS and CAL-27 cells.

Liriopesides B purchased from MedChemExpress. Usage Cited in: Transl Cancer Res. 2025 Oct 31;14(10):6637-6652. [Abstract]

The effect of Liriopesides B (LPB) (12, 24 μM) on the protein expression of PI3K, Akt, p-Akt, mTOR, p-mTOR, S6, p-S6, 4EBP1, and p-4EBP1 in SAS cells.

Liriopesides B purchased from MedChemExpress. Usage Cited in: Transl Cancer Res. 2025 Oct 31;14(10):6637-6652. [Abstract]

SC79 reverses the Liriopesides B (LPB) (12, 24 μM)-induced CAL-27 and SAS cells viability inhibition.

Liriopesides B purchased from MedChemExpress. Usage Cited in: Transl Cancer Res. 2025 Oct 31;14(10):6637-6652. [Abstract]

Liriopesides B (LPB) (12, 24 μM) inhibits the invasion ability of SAS and CAL-27 cells.

Liriopesides B purchased from MedChemExpress. Usage Cited in: Transl Cancer Res. 2025 Oct 31;14(10):6637-6652. [Abstract]

The effect of Liriopesides B (LPB) (5, 10 mg/kg) on tumor volume in SAS xenograft nude mice.

Lösungsmittel & Löslichkeit

In Vitro:

DMSO : 100 mg/mL (138.33 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

1.3833 mL

6.9166 mL

13.8332 mL

5 mM

0.2767 mL

1.3833 mL

2.7666 mL

10 mM

0.1383 mL

0.6917 mL

1.3833 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

Stock Solution Working Solution

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline

Solubility: ≥ 2.5 mg/mL (3.46 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)

Solubility: ≥ 2.5 mg/mL (3.46 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil

Solubility: ≥ 2.5 mg/mL (3.46 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage Dosage
mg/kg
Animal Weight (Per Animal) Animal Weight (Per Animal)
g
Dosing Volume (Per Animal) Dosing Volume (Per Animal)
μL
Number of Animals Number of Animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

%
DMSO +

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
%
+
+
%
Tween-80 + +
%
Saline +

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Working solution concentration: 0.22 mg/mL

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (276 KB)
SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Sun K, et al. A Steroidal Saponin from Ophiopogon japonicus Extends the Lifespan of Yeast via the Pathway Involved in SOD and UTH1. Int J Mol Sci. 2013 Feb 25;14(3):4461-75. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	1.3833 mL	6.9166 mL	13.8332 mL	34.5829 mL
	5 mM	0.2767 mL	1.3833 mL	2.7666 mL	6.9166 mL
	10 mM	0.1383 mL	0.6917 mL	1.3833 mL	3.4583 mL
	15 mM	0.0922 mL	0.4611 mL	0.9222 mL	2.3055 mL
	20 mM	0.0692 mL	0.3458 mL	0.6917 mL	1.7291 mL
	25 mM	0.0553 mL	0.2767 mL	0.5533 mL	1.3833 mL
	30 mM	0.0461 mL	0.2306 mL	0.4611 mL	1.1528 mL
	40 mM	0.0346 mL	0.1729 mL	0.3458 mL	0.8646 mL
	50 mM	0.0277 mL	0.1383 mL	0.2767 mL	0.6917 mL
	60 mM	0.0231 mL	0.1153 mL	0.2306 mL	0.5764 mL
	80 mM	0.0173 mL	0.0865 mL	0.1729 mL	0.4323 mL
	100 mM	0.0138 mL	0.0692 mL	0.1383 mL	0.3458 mL

Keywords

Liriopesides B

1 Cited Publications

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Liriopesides B

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Publications Citing Use of MedChemExpress (MCE) Liriopesides B

Biologische Aktivität

Chemical Information

Publications (1)

Lösungsmittel & Löslichkeit

Reinheit & Dokumentation

Verweise

Help & FAQs

Complete Stock Solution Preparation Table

Liriopesides B

Immunology/Inflammation Compound Library

Natural Product Library

Anti-Cancer Compound Library

Anti-Aging Compound Library

Glycoside Compound Library

Traditional Chinese Medicine Active Compound Library

Anti-Cancer Natural Product Library

Anti-inflammatory Traditional Chinese Medicine Active Compound Library

Plant-Sourced Natural Product Library

Anti-Pulmonary Fibrosis Compound Library

Anti-Aging Natural Product Library

Heterocyclic Compound Library

Bioactive Compound Library Max

MCE Bioactive Compound Library

Natural Product Library Plus

Natural Product and Natural Product-Like Compound Library

Bioactive Compound Library

Miao Ethnicity Medicine Compound Library

Protein Kinase Compound Library

High-Throughput Bioactive Compound Library

High-Throughput Natural Product Library

Ancient Chinese Classical Formulas Traditional Chinese Medicine Active Compound Library

Antitussive and Antiasthmatic Traditional Chinese Medicine Active Compound Library

Diarrhea-Related Traditional Chinese Medicine Active Compound Library

Mongolian Medicine Compound Library

Natural Product Diversity Scaffold Library

Tonifying Traditional Chinese Medicine Monomer Compound Library

Mass Spectrometry Natural Product Library

Publications Citing Use of MedChemExpress (MCE) Liriopesides B

Biologische Aktivität

Chemical Information

Publications (1)

Lösungsmittel & Löslichkeit

Reinheit & Dokumentation

Verweise

Help & FAQs

Complete Stock Solution Preparation Table

Liriopesides B Related Classifications

HY-N5135 Related Classifications