Art. -Nr.: HY-N4136

Lonicerin

(Synonyms: Veronicastroside)

1 Cited Publications

Kundenbewertung

Based on 1 publication(s) in Google Scholar

Lonicerin (Veronicastroside) is a flavonoid with multiple biological activities. Lonicerin inhibits xanthine oxidase with an IC₅₀ of 37.4 µg/mL. Lonicerin inhibits alginate secretion protein (AlgE). Lonicerin inhibits P. aeruginosa and C. albicans. Lonicerin has anti-inflammatory, anti-arthritic, antioxidant, antifungal, anti-bacterial, and neuroprotective properties.

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Reinheit: 99.77%
CAS. Nr.: 25694-72-8
Formel: C₂₇H₃₀O₁₅
Molecular Weight:594.52

Speicherung:

4°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Lonicerin Chemical Structure

CAS. Nr.: 25694-72-8

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Publications Citing Use of MedChemExpress (MCE) Lonicerin

Exp Anim.2024 May 3;73(2):154-161. [Abstract]

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Histological Imaging/StainingELISAWBIF

Histological Imaging/Staining
ELISA
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Biologische Aktivität
- Beschreibung
- In Vitro
- In Vivo
Chemical Information
Publications (1)
Lösungsmittel & Löslichkeit
- In Vitro
- In Vivo
Reinheit & Dokumentation
Verweise
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

In Vitro

Lonicerin could significantly reduce alginate secretion (25 μg/mL) and biofilm formation (12.5 μg/mL) at a sub-MIC concentration without inhibiting the proliferation of P. aeruginosa or influencing the expression of AlgE, which suggested that Lonicerin may directly inhibit AlgE^[1].
Lonicerin inhibits the infection of P. aeruginosa in the A549 cells^[1].
Lonicerin (5-40 µg/mL; 48 h) suppresses T cell proliferation, increases the production of Th2 cytokines such as IL-4 and IL-10, resulting in switch from Th1 to Th2-type responses^[2].
Lonicerin (0-40 µg/mL) inhibits nitric oxide (NO) production from macrophages^[2].
Lonicerin (10-100 µg/mL; 48 h) inhibits C.albicans growth. The antifungal activity is concentration dependent^[2].
Lonicerin scavenges DPPH (HY-112053), hydroxyl, and superoxide radicals, with IC₅₀ values of 9.2 µg/mL, 236.8 µg/mL, and 143.9 µg/mL, respectively^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[2]

Cell Line:

T cells
Concentration:

5 µg/mL, 10 µg/mL, 20 µg/mL, and 40 µg/mL
Incubation Time:

48 h
Result:

Suppressed T cell proliferation.

In Vivo

Lonicerin (1-2 mg/mouse; i.p.; 3 times; every other day) reduces paw edema in a mouse model of C. albicans cell wall- and complete Freund’s adjuvant-induced arthritis^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

BALB/c female mice (6-7 weeks) injected with an emulsified mixture of C. albicans cell wall (CACW) and complete Freund's adjuvant (CACW/CFA) via hind footpad route on days -3, -2, and -1^[2].
Dosage:

1 mg/mouse or 2 mg/mouse
Administration:

i.p.; 3 times; every other day
Result:

Reduced the edema at all dose levels.

Chemical Information

CAS. Nr. 25694-72-8
Appearance Solid
Molecular Weight 594.52
Formel C₂₇H₃₀O₁₅
Color Light yellow to yellow
SMILES

O=C1C2=C(O)C=C(O[C@H]3[C@@H]([C@H]([C@H](O)[C@@H](CO)O3)O)O[C@@]4([H])[C@@H]([C@@H]([C@@H](O)[C@H](C)O4)O)O)C=C2OC(C5=CC(O)=C(O)C=C5)=C1
Synonyms

Veronicastroside
Structure Classification
- Flavonoids
- Flavones
- Phenols
- Polyphenols
Initial Source
- Plants
- Caprifoliaceae
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

4°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Publications (1)

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Exp Anim

Lonicerin alleviates ovalbumin-induced asthma of mice via inhibiting enhancer of zeste homolog 2/nuclear factor-kappa B signaling pathway. [Abstract]

2024 May 3;73(2):154-161. PMID: 37952975

Lonicerin purchased from MedChemExpress. Usage Cited in: Exp Anim.2024 May 3;73(2):154-161. [Abstract]

Histopathological changes in lung tissue were detected by hematoxylin and eosin (H&E) staining treated with Lonicerin (10, 30 mg/kg, i.g.).

Lonicerin purchased from MedChemExpress. Usage Cited in: Exp Anim.2024 May 3;73(2):154-161. [Abstract]

IL-4, IL-5 and IL-13 concentrations in lung tissue were measured by ELISA treated with Lonicerin (10, 30 mg/kg, i.g.).

Lonicerin purchased from MedChemExpress. Usage Cited in: Exp Anim.2024 May 3;73(2):154-161. [Abstract]

Western blot was used to analyzed the expression of EZH2 and tri-methylation of histone H3 at lysine 27 (H3K27me3) in lung tissue treated with Lonicerin (10, 30 mg/kg, i.g.).

Lonicerin purchased from MedChemExpress. Usage Cited in: Exp Anim.2024 May 3;73(2):154-161. [Abstract]

The expression and location of NF-κB p65 in lung tissue were assessed by immunofluorescence analysis treated with Lonicerin (10, 30 mg/kg, i.g.).

Lösungsmittel & Löslichkeit

In Vitro:

DMSO : 25 mg/mL (42.05 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

1.6820 mL

8.4101 mL

16.8203 mL

5 mM

0.3364 mL

1.6820 mL

3.3641 mL

10 mM

0.1682 mL

0.8410 mL

1.6820 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

Stock Solution Working Solution

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline

Solubility: ≥ 2.5 mg/mL (4.21 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)

Solubility: ≥ 2.5 mg/mL (4.21 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage Dosage
mg/kg
Animal Weight (Per Animal) Animal Weight (Per Animal)
g
Dosing Volume (Per Animal) Dosing Volume (Per Animal)
μL
Number of Animals Number of Animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

%
DMSO +

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
%
+
+
%
Tween-80 + +
%
Saline +

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Working solution concentration: 0.22 mg/mL

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (277 KB)
SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
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- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Xu Z, et al. Lonicerin, an anti-algE flavonoid against Pseudomonas aeruginosa virulence screened from Shuanghuanglian formula by molecule docking based strategy. J Ethnopharmacol. 2019 Jul 15;239:111909. [Content Brief]

[2]. Lee JH, et al. Antiarthritic effect of lonicerin on Candida albicans arthritis in mice. Arch Pharm Res. 2011 May;34(5):853-9. [Content Brief]

[3]. Xiao Ding, et al. Evaluation of Anti-MRSA and Xanthine Oxidase Inhibition Activities of Phenolic Constituents from Plumula nelumbinis. Journal of Chemistry. 24 December 2015.

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	1.6820 mL	8.4101 mL	16.8203 mL	42.0507 mL
	5 mM	0.3364 mL	1.6820 mL	3.3641 mL	8.4101 mL
	10 mM	0.1682 mL	0.8410 mL	1.6820 mL	4.2051 mL
	15 mM	0.1121 mL	0.5607 mL	1.1214 mL	2.8034 mL
	20 mM	0.0841 mL	0.4205 mL	0.8410 mL	2.1025 mL
	25 mM	0.0673 mL	0.3364 mL	0.6728 mL	1.6820 mL
	30 mM	0.0561 mL	0.2803 mL	0.5607 mL	1.4017 mL
	40 mM	0.0421 mL	0.2103 mL	0.4205 mL	1.0513 mL

Keywords

Lonicerin

1 Cited Publications

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Lonicerin

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Publications Citing Use of MedChemExpress (MCE) Lonicerin

Biologische Aktivität

Chemical Information

Publications (1)

Lösungsmittel & Löslichkeit

Reinheit & Dokumentation

Verweise

Help & FAQs

Complete Stock Solution Preparation Table

Lonicerin Related Classifications

Art. -Nr.: HY-N4136