LQFM215
Based on 1 Customer Validation
LQFM215 is a proline transporter (PROT) inhibitor. LQFM215 inhibits proline transport by competitively binding to the active site of PROT. LQFM215 effectively reduces hyperlocomotion and enhances social interaction.
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- Reinheit: 99.80%
- CAS. Nr.: 3044047-98-2
- Formel: C25H34N2O2
- Molecular Weight:394.55
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Speicherung:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biologische Aktivität
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Chemical Information
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Lösungsmittel & Löslichkeit
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
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Biologische Aktivität
LQFM215 (0.39-100 μM; 24 h ) shows low neurotoxicity against LUHMES cells[1].
LQFM215 (0.09-100 μM; 24 h ) shows concentration-dependent effects on growth of differentiated neural protrusions and cell survival in LUHMES cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:LUHMES cells
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Concentration:0.09-100 μM
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Incubation Time:24 h
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Result:During the developmental phase, neural protrusion formation was inhibited at an IC50 of 3 μM. During maturation, a concentration of 14 μM IC50 reduced neural protrusion growth and cell survival.
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Cell Line:LUHMES cells
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Concentration:0.39-100 μM
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Incubation Time:24 h
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Result:Reduced cell viability and neural protrusion growth in LUHMES cells, but this effect was mitigated when co-cultured with astrocytes
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Male Swiss mice [1]
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Dosage:10; 20; 30 mg/kg
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Administration:i.p.; single dose
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Result:Increased the time spent in social interaction with an intruder animal in ketamine-treated mice across all doses, particularly at 10 mg/kg and 20 mg/kg. Increased the number of social interactions at 30 mg/kg.
Chemical Information
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CAS. Nr. 3044047-98-2
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Appearance Solid
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Molecular Weight 394.55
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Formel C25H34N2O2
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Color White to off-white
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SMILES
O=C(C1=CC(C(C)(C)C)=C(O)C(C(C)(C)C)=C1)N(CC2)CCN2C3=CC=CC=C3
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Lösungsmittel & Löslichkeit
DMSO : 100 mg/mL (253.45 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL.
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Reinheit & Dokumentation
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Data Sheet (274 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
Verweise
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.5345 mL | 12.6727 mL | 25.3453 mL | 63.3633 mL |
| 5 mM | 0.5069 mL | 2.5345 mL | 5.0691 mL | 12.6727 mL | |
| 10 mM | 0.2535 mL | 1.2673 mL | 2.5345 mL | 6.3363 mL | |
| 15 mM | 0.1690 mL | 0.8448 mL | 1.6897 mL | 4.2242 mL | |
| 20 mM | 0.1267 mL | 0.6336 mL | 1.2673 mL | 3.1682 mL | |
| 25 mM | 0.1014 mL | 0.5069 mL | 1.0138 mL | 2.5345 mL | |
| 30 mM | 0.0845 mL | 0.4224 mL | 0.8448 mL | 2.1121 mL | |
| 40 mM | 0.0634 mL | 0.3168 mL | 0.6336 mL | 1.5841 mL | |
| 50 mM | 0.0507 mL | 0.2535 mL | 0.5069 mL | 1.2673 mL | |
| 60 mM | 0.0422 mL | 0.2112 mL | 0.4224 mL | 1.0561 mL | |
| 80 mM | 0.0317 mL | 0.1584 mL | 0.3168 mL | 0.7920 mL | |
| 100 mM | 0.0253 mL | 0.1267 mL | 0.2535 mL | 0.6336 mL |
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