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Art. -Nr.: HY-130408

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m-PEG6-Amine

1 Cited Publications

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m-PEG6-Amine is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. m-PEG6-Amine is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

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Reinheit: 98.0%
CAS. Nr.: 184357-46-8
Formel: C₁₃H₂₉NO₆
Molecular Weight:295.37

Speicherung:

4°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

m-PEG6-Amine Chemical Structure

CAS. Nr.: 184357-46-8

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Biologische Aktivität
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- IC₅₀ & Target
- In Vitro
Chemical Information
Publications (1)
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Calculators
Help & FAQs
Classifications
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Beschreibung

m-PEG6-Amine is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. m-PEG6-Amine is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)^[1].

IC₅₀ & Target^[1]^[2]

Cleavable Linker

PEGs

Alle ADC Linkers Isoform-spezifische Produkte anzeigen :

Alle PROTAC Linkers Isoform-spezifische Produkte anzeigen :

In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS. Nr. 184357-46-8
Appearance Liquid (Density: 1.036±0.06 g/cm³)
Molecular Weight 295.37
Formel C₁₃H₂₉NO₆
Color Colorless to light yellow
SMILES

COCCOCCOCCOCCOCCOCCN
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

4°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Publications (1)

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Sep Purif Technol

2025 Dec 22.

Reinheit & Dokumentation

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Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (264 KB)
SDS (477 KB)
- English - EN (477 KB)
- Français - FR (477 KB)
- Deutsch - DE (477 KB)
- Norwegian - NO (477 KB)
- Español - ES (477 KB)
- Swedish - SV (477 KB)
- Italian - IT (477 KB)
- Korean - KR (477 KB)
- Portuguese - PT (477 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Hervé Bouchard, et al. Peptidic linkers and cryptophycin conjugates, useful in therapy, and their preparation. WO2018206635A1.

[2]. Austin G Wardrip, et al. Length-Independent Charge Transport in Chimeric Molecular Wires. Angew Chem Int Ed Engl. 2016 Nov 7;55(46):14267-14271. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

m-PEG6-Amine

1 Cited Publications

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Biologische Aktivität
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- IC₅₀ & Target
- In Vitro
Chemical Information
Publications (1)
Reinheit & Dokumentation
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m-PEG6-Amine

Publications Citing Use of MedChemExpress (MCE) m-PEG6-Amine

Alle ADC Linkers Isoform-spezifische Produkte anzeigen

Alle PROTAC Linkers Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Publications (1)

Reinheit & Dokumentation

Verweise

Calculators

Help & FAQs

m-PEG6-Amine Related Classifications

HY-130408 Related Classifications