MNI-135
MNI-135 is a selective group II metabotropic glutamate receptor (mGluR) inhibitor. MNI-135 shows no inhibitory activity against group I or group III mGluRs.
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- CAS. Nr.: 335257-47-1
- Formel: C16H10IN3O
- Molecular Weight:387.18
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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Biologische Aktivität
Beschreibung
IC50 & Target
[1]|
mGluR2 |
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HEK293-A | IC50 |
19.6 nM
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Inhibition of glutamate-induced calcium mobilization in HEK293A cells expressing rat mGluR2 measured via calcium indicator dye and FLEXstation II after 5 min preincubation with MNI-135 followed by glutamate stimulation.
Inhibition of glutamate-induced calcium mobilization in HEK293A cells expressing rat mGluR2 measured via calcium indicator dye and FLEXstation II after 5 min preincubation with MNI-135 followed by glutamate stimulation.
|
17416742 |
| HEK293-A | IC50 |
21.4 nM
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Inhibition of glutamate-induced calcium mobilization in HEK293A cells expressing wild-type human mGluR2 measured via calcium indicator dye and FLEXstation II after 5 min preincubation with MNI-135 followed by glutamate stimulation.
Inhibition of glutamate-induced calcium mobilization in HEK293A cells expressing wild-type human mGluR2 measured via calcium indicator dye and FLEXstation II after 5 min preincubation with MNI-135 followed by glutamate stimulation.
|
17416742 |
| HEK293-A | IC50 |
24.4 nM
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Inhibition of glutamate-induced calcium mobilization in HEK293A cells expressing N735D mutant human mGluR2 measured via calcium indicator dye and FLEXstation II after 5 min preincubation with MNI-135 followed by glutamate stimulation.
Inhibition of glutamate-induced calcium mobilization in HEK293A cells expressing N735D mutant human mGluR2 measured via calcium indicator dye and FLEXstation II after 5 min preincubation with MNI-135 followed by glutamate stimulation.
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17416742 |
In Vitro
MNI-135 potently inhibits glutamate-induced calcium mobilization in HEK293A cells expressing rmGluR2, with an IC50 of 19.6 nM[1].
MNI-135 potently inhibits glutamate-induced calcium mobilization in CHO cells expressing hmGluR2, with an IC50 value of 10.51 nM[1].
MNI-135 inhibits [35S]GTPγS binding to glutamate-stimulated CHO cell membranes expressing hmGluR2, with an IC50 of 118.2 nM[1].
MNI-135 (60 min) inhibits glutamate-induced [35S]GTPγS binding to membranes of CHO cells expressing rmGluR3, with an IC50 of 30.2 nM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. .
Chemical Information
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CAS. Nr. 335257-47-1
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Molecular Weight 387.18
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Formel C16H10IN3O
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SMILES
N#CC1=CC=CC(=C1)C2=NC3=CC=C(I)C=C3NC(=O)C2
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
MNI-135 Related Classifications
HY-119474 Related Classifications
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