Neorauflavane
Based on 1 Customer Validation
Neorauflavane is a tyrosinase inhibitor with mushroom tyrosinase IC50 values of 30 nM and 500 nM, and Ki values of 19 nM and 130 nM. Neorauflavane inhibits monophenolase and diphenolase activities, binds to tyrosinase’s active site via its B-ring resorcinol motif and A-ring methoxy group. Neorauflavane reduces melanin synthesis in melanoma cells. Neorauflavane can be used for the research of skin hyperpigmentation.
Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.
- Reinheit: 96.0%
- CAS. Nr.: 53734-74-0
- Formel: C21H22O5
- Molecular Weight:354.40
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Speicherung:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biologische Aktivität
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Chemical Information
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Help & FAQs
Biologische Aktivität
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Cell Line
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Type | Value | Description | References |
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| B16 | IC50 |
13 μM
Compound: 3
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Inhibition of alpha-MSH-stimulated melanin production in mouse B16 cells after 72 hrs by microplate reader analysis
Inhibition of alpha-MSH-stimulated melanin production in mouse B16 cells after 72 hrs by microplate reader analysis
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[PMID: 26706112] |
Neorauflavane (Compound 3) (0-140 nM; 10-25 min) potently inhibits the monophenolase activity of mushroom tyrosinase via a competitive, simple reversible slow-binding inhibition mode, with an IC50 of 30 nM and a Ki of 19 nM[1].
Neorauflavane (0-720 μM; 25 min) inhibits the diphenolase activity of mushroom tyrosinase via competitive inhibition, with an IC50 of 500 nM and a Ki of 130 nM[1].
Neorauflavane (0-20 μM; 72 h) reduces α-MSH (HY-P0252)-stimulated melanin content in B16 mouse melanoma cells in a dose-dependent manner, with an IC50 of 13 μM, and shows no cytotoxicity at effective concentrations[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS. Nr. 53734-74-0
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Appearance Solid
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Molecular Weight 354.40
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Formel C21H22O5
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Color White to off-white
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SMILES
COC1=C2C(OC[C@@H](C3=C(C=C(O)C=C3)O)C2)=CC4=C1C=CC(C)(C)O4
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Structure Classification
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Initial Source
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Reinheit & Dokumentation
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Data Sheet (268 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Neorauflavane Related Classifications
HY-N3200 Related Classifications
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