Art. -Nr.: HY-Y0057

4-Quinolinecarboxylic acid

Name: 4-Quinolinecarboxylic acid
Brand: MedChemExpress
SKU: HY-Y0057
Price: 25.00 USD
Availability: InStock
Rating: 5 (1 reviews)

(Synonyms: Cinchoninic acid; 4-Carboxyquinoline; NSC 13138)

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4-Quinolinecarboxylic acid (Cinchoninic acid; 4-Carboxyquinoline; NSC 13138) is a quinoline derivative and also an Endogenous Metabolite. 4-Quinolinecarboxylic acid can serve as the sole carbon source for the growth of the soil bacterium Microbacterium sp. H2.

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Reinheit : 99.58%
CAS. Nr.: 486-74-8
Formel: C₁₀H₇NO₂
Molecular Weight:173.17

Speicherung:

Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month

4-Quinolinecarboxylic acid Chemical Structure

CAS. Nr.: 486-74-8

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Biologische Aktivität
- Beschreibung
- Cellular Effect
- In Vitro
Chemical Information
Lösungsmittel & Löslichkeit
- In Vitro
- In Vivo
Reinheit & Dokumentation
Verweise
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

Alle Endogenous Metabolite Isoform-spezifische Produkte anzeigen :

Cellular Effect

Cell Line	Type	Value	Description	References
A549	IC₅₀	>50 μM Compound: QLin	Antiproliferative activity against human A549 cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay Antiproliferative activity against human A549 cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay	[PMID: 37956506]
HCT-116	IC₅₀	>50 μM Compound: QLin	Antiproliferative activity against human HCT-116 cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay Antiproliferative activity against human HCT-116 cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay	[PMID: 37956506]
MCF-10A	IC₅₀	>50 μM Compound: QLin	Cytotoxicity against human MCF-10A cells assessed as cell growth inhibition measured after 48 hrs by MTT assay Cytotoxicity against human MCF-10A cells assessed as cell growth inhibition measured after 48 hrs by MTT assay	[PMID: 37956506]
MCF7	IC₅₀	>50 μM Compound: QLin	Antiproliferative activity against human MCF7 cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay Antiproliferative activity against human MCF7 cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay	[PMID: 37956506]
NCI/ADR-RES	IC₅₀	>50 μM Compound: QLin	Antiproliferative activity against human MCF7ADR cells assessed as inhibition of cell growth measured after 48 hrs by MTT assay Antiproliferative activity against human MCF7ADR cells assessed as inhibition of cell growth measured after 48 hrs by MTT assay	[PMID: 37956506]

In Vitro

4-Quinolinecarboxylic acid serves as the sole carbon source to support the growth of *Microbacterium* sp. H2. When the mutant strain M17 is co-cultured with this substrate and Succinic acid (HY-N0420), it sequentially produces two metabolites, namely 2-oxo-1,2-dihydroquinoline-4-carboxylic acid and 8-hydroxy-2-oxo-2H-1-benzopyran-4-carboxylic acid, both of which can independently act as carbon sources for the wild-type strain. Substrate degradation initiates with the oxidation at the C2 position of the pyridine ring^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS. Nr. 486-74-8
Appearance Solid
Molecular Weight 173.17
Formel C₁₀H₇NO₂
Color Light brown to brown
SMILES

O=C(C1=CC=NC2=CC=CC=C12)O
Synonyms

Cinchoninic acid; 4-Carboxyquinoline; NSC 13138
Structure Classification
- Ketones, Aldehydes, Acids
Initial Source
- Endogenous metabolite
Versand

Room temperature in continental US; may vary elsewhere.

Speicherung

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Lösungsmittel & Löslichkeit

In Vitro:

DMSO : 50 mg/mL (288.73 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

5.7747 mL

28.8734 mL

57.7467 mL

5 mM

1.1549 mL

5.7747 mL

11.5493 mL

10 mM

0.5775 mL

2.8873 mL

5.7747 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

Stock Solution Working Solution

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline

Solubility: ≥ 2.5 mg/mL (14.44 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)

Solubility: ≥ 2.5 mg/mL (14.44 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil

Solubility: ≥ 2.5 mg/mL (14.44 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage Dosage
mg/kg
Animal Weight (Per Animal) Animal Weight (Per Animal)
g
Dosing Volume (Per Animal) Dosing Volume (Per Animal)
μL
Number of Animals Number of Animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

%
DMSO +

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
%
+
+
%
Tween-80 + +
%
Saline +

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Working solution concentration: 0.22 mg/mL

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (293 KB)
SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Röger P. Degradation of quinoline-4-carboxylic acid by Microbacterium sp. FEMS Microbiol Lett. 1989;57(3):279‐282

[2]. Sabt A, et al. Identification of 2-(-aryl-1,2,3-triazol-4-yl) quinoline derivatives as antitubercular agents endowed with InhA inhibitory activity. Frontiers in chemistry. 2024;12:1424017. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	5.7747 mL	28.8734 mL	57.7467 mL	144.3668 mL
	5 mM	1.1549 mL	5.7747 mL	11.5493 mL	28.8734 mL
	10 mM	0.5775 mL	2.8873 mL	5.7747 mL	14.4367 mL
	15 mM	0.3850 mL	1.9249 mL	3.8498 mL	9.6245 mL
	20 mM	0.2887 mL	1.4437 mL	2.8873 mL	7.2183 mL
	25 mM	0.2310 mL	1.1549 mL	2.3099 mL	5.7747 mL
	30 mM	0.1925 mL	0.9624 mL	1.9249 mL	4.8122 mL
	40 mM	0.1444 mL	0.7218 mL	1.4437 mL	3.6092 mL
	50 mM	0.1155 mL	0.5775 mL	1.1549 mL	2.8873 mL
	60 mM	0.0962 mL	0.4812 mL	0.9624 mL	2.4061 mL
	80 mM	0.0722 mL	0.3609 mL	0.7218 mL	1.8046 mL
	100 mM	0.0577 mL	0.2887 mL	0.5775 mL	1.4437 mL

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4-Quinolinecarboxylic acid

Alle Endogenous Metabolite Isoform-spezifische Produkte anzeigen