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Art. -Nr.: HY-168017

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NSC682769

NSC682769 is a PROTAC YAP-targeting ligand (Ligands for Target Protein for PROTACs). NSC682769 can be used for synthesis PROTAC YAP degrader-1 (HY-168016).

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CAS. Nr.: 205048-79-9
Formel: C₂₇H₂₂N₂O₃
Molecular Weight:422.48

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (274 KB)

NSC682769 Chemical Structure

CAS. Nr.: 205048-79-9

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- Cellular Effect
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

NSC682769 is a PROTAC YAP-targeting ligand (Ligands for Target Protein for PROTACs). NSC682769 can be used for synthesis PROTAC YAP degrader-1 (HY-168016)^[1].

Alle YAP Isoform-spezifische Produkte anzeigen :

Cellular Effect

Cell Line	Type	Value	Description	References
Huh-7	IC₅₀	69 μM Compound: 6 : NSC682769	Antiproliferative activity against human Huh-7 cells overexpressing YAP assessed as cell growth inhibition incubated for 4 days by CCK-8 assay Antiproliferative activity against human Huh-7 cells overexpressing YAP assessed as cell growth inhibition incubated for 4 days by CCK-8 assay	[PMID: 39189384]
NCI-H226	IC₅₀	3.9 μM Compound: 6 : NSC682769	Antiproliferative activity against NF2 deficient- human NCI-H226 cells assessed as cell growth inhibition incubated for 4 days by CCK-8 assay Antiproliferative activity against NF2 deficient- human NCI-H226 cells assessed as cell growth inhibition incubated for 4 days by CCK-8 assay	[PMID: 39189384]

Chemical Information

CAS. Nr. 205048-79-9
Molecular Weight 422.48
Formel C₂₇H₂₂N₂O₃
SMILES

O=C1NC2=CC=CC=C2C3=NC(C4=CC=CC=C4)=CC(C(C=C5OC)=CC=C5OC)=C3C1
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (274 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Zhou C, et al. Exploring Degradation of Intrinsically Disordered Protein Yes-Associated Protein Induced by Proteolysis TArgeting Chimeras. J Med Chem. 2024 Sep 12;67(17):15168-15198. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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