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Art. -Nr.: HY-183774

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NTQ2494

NTQ2494 is a potent and orally active AXL kinase inhibitor with an IC₅₀ of 4.89 nM. NTQ2494 inhibits AXL kinase catalytic activity. NTQ2494 suppresses tumor growth in mouse xenograft models. NTQ2494 can be used for the research of advanced hematological malignancies, solid tumors.

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CAS. Nr.: 2750027-59-7
Formel: C₂₉H₃₇ClN₅O₂P
Molecular Weight:554.06

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

NTQ2494 Chemical Structure

CAS. Nr.: 2750027-59-7

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Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
- Parmacokinetics
- In Vivo
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

IC₅₀ & Target^[1]

Axl

4.89 nM (IC₅₀)

Alle TAM Receptor Isoform-spezifische Produkte anzeigen :

In Vitro

NTQ2494 (0-10 μM; 72 h) inhibits proliferation of MV-4-11, MOLM-13, K-562, KATO III, HCT-116, SW48, MIA PaCa-2, and TOV-21G cancer cells with IC₅₀ values of 0.007, 0.008, 0.030, 0.023, 0.100, 0.019, 0.033, and 0.099 μM^[1].
NTQ2494 (1-100 μM) inhibits hERG channels in HEK-293-hERG cells with an IC₅₀ of 36.49 μM, indicating low cardiotoxicity risk^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Parmacokinetics

Species	Dose	Route	T_1/2	CL	V_dss	AUC_0-24	F
Rat^[1]	2.5 mg/kg	i.v.	4.66 h	4.98 L/h/kg	16.0 L/kg	/	/
Rat^[1]	2.5 mg/kg	p.o.	4.87 h	/	/	101 ng·h/mL	19.69 %
Dog^[1]	0.75 mg/kg	i.v.	3.94 h	1.67 L/h/kg	5.11 L/kg	/	/
Dog^[1]	0.75 mg/kg	p.o.	4.21 h	/	/	157 ng·h/mL	34.43 %

In Vivo

NTQ2494 (2.5-10 mg/kg; p.o.; once daily; 21 days) dose-dependently inhibits MV-4-11 xenograft tumor growth in nude mice^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Female nude mice (18-20 g) subcutaneously inoculated with MV-4-11 cells^[1]
Dosage:

2.5; 5; 10 mg/kg
Administration:

p.o.; once daily; 21 days
Result:

Achieved a tumor growth inhibition (TGI) rate of 46% at 2.5 mg/kg.
Achieved a TGI rate of 91% at 5 mg/kg.
Achieved a TGI rate of 108% at 10 mg/kg.
Showed no significant changes in body weight across all dose.

Chemical Information

CAS. Nr. 2750027-59-7
Molecular Weight 554.06
Formel C₂₉H₃₇ClN₅O₂P
SMILES

ClC1=C(NC2=CC=C(COC)C=C2P(C)(C)=O)N=C(NC3=CC(CC[C@@H](N4CCCC4)CC5)=C5C=C3)N=C1
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Handling Instructions (2659 KB)

Verweise

[1]. Zhang LL, et al. Discovery of NTQ2494, a potent and orally bioavailable inhibitor of AXL kinase for the treatment of human tumors. Eur J Med Chem. Published online May 17, 2026. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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