Art. -Nr.: HY-B1986

p,p'-DDE

(Synonyms: 4,4'-DDE; p,p'-Dichlorodiphenyldichloroethylene)

2 Cited Publications

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Based on 2 publication(s) in Google Scholar

p,p'-DDE (4,4'-DDE) is the major and persistent metabolite of DDT. p,p'-DDE is a orally active androgen receptor antagonist with an IC₅₀ of 5 μM and a K_i of 3.5 μM. p,p'-DDE can affect the development and function of the male reproductive system. Additionally, high serum concentrations of p,p'-DDE may be a risk factor for type 2 diabetes in women.

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Reinheit: 99.91%
CAS. Nr.: 72-55-9
Formel: C₁₄H₈Cl₄
Molecular Weight:318.03

Speicherung:

4°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

p,p'-DDE Chemical Structure

CAS. Nr.: 72-55-9

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Biologische Aktivität
- Beschreibung
- In Vitro
- In Vivo
Chemical Information
Publications (2)
Lösungsmittel & Löslichkeit
- In Vitro
- In Vivo
Reinheit & Dokumentation
Verweise
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

In Vitro

p,p'-DDE (0.2 μM) can effectively inhibit the transcriptional activity of the androgen receptor induced by androgens^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

p,p'-DDE (100 mg/kg; oral gavage; gestational days 14-18) can lead to a reduced anogenital distance at birth and retention of thoracic nipples at 13 days old in male rat pups^[1].
p,p'-DDE (100 mg/kg; oral gavage; from 25-57 days old) can delay the onset of puberty in weanling male rats, while increasing their body weight and without reducing the serum testosterone levels^[1].
p,p'-DDE (200 mg/kg; oral gavage; 4 days) can significantly reduce the weights of androgen-dependent seminal vesicles and prostates and alter related gene expression in 120-day-old male rats^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS. Nr. 72-55-9
Appearance Solid
Molecular Weight 318.03
Formel C₁₄H₈Cl₄
Color White to off-white
SMILES

Cl/C(Cl)=C(C1=CC=C(Cl)C=C1)/C2=CC=C(Cl)C=C2
Synonyms

4,4'-DDE; p,p'-Dichlorodiphenyldichloroethylene
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

4°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Publications (2)

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Journal Impact Factor

Anal Chem

Exposome-Scale Investigation of Cl-/Br-Containing Chemicals Using High-Resolution Mass Spectrometry, Multistage Machine Learning, and Cloud Computing. [Abstract]

2025 Jun 3;97(21):11099-11109. PMID: 40401576
Ecotoxicol Environ Saf

Mechanistic investigation of DDT/DDE in MASLD/MASH pathogenesis: An integrated network toxicology and transcriptomics approach. [Abstract]

2025 Nov 15:307:119390. PMID: 41232492

Lösungsmittel & Löslichkeit

In Vitro:

DMSO : 100 mg/mL (314.44 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

3.1444 mL

15.7218 mL

31.4436 mL

5 mM

0.6289 mL

3.1444 mL

6.2887 mL

10 mM

0.3144 mL

1.5722 mL

3.1444 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

Stock Solution Working Solution

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline

Solubility: ≥ 2.5 mg/mL (7.86 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

Protocol 2

Add each solvent one by one: 10% DMSO 90% Corn Oil

Solubility: ≥ 2.5 mg/mL (7.86 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage Dosage
mg/kg
Animal Weight (Per Animal) Animal Weight (Per Animal)
g
Dosing Volume (Per Animal) Dosing Volume (Per Animal)
μL
Number of Animals Number of Animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

%
DMSO +

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
%
+
+
%
Tween-80 + +
%
Saline +

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Working solution concentration: 0.22 mg/mL

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (277 KB)
SDS (788 KB)
- English - EN (788 KB)
- Français - FR (788 KB)
- Deutsch - DE (788 KB)
- Norwegian - NO (788 KB)
- Español - ES (788 KB)
- Swedish - SV (788 KB)
- Italian - IT (788 KB)
- Korean - KR (788 KB)
- Portuguese - PT (788 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Kelce WR, et al. Persistent DDT metabolite p,p'-DDE is a potent androgen receptor antagonist. Nature. 1995;375(6532):581-585. [Content Brief]

[2]. Rignell-Hydbom A, et al. Exposure to p,p'-DDE: a risk factor for type 2 diabetes. PLoS One. 2009 Oct 19;4(10):e7503. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	3.1444 mL	15.7218 mL	31.4436 mL	78.6089 mL
	5 mM	0.6289 mL	3.1444 mL	6.2887 mL	15.7218 mL
	10 mM	0.3144 mL	1.5722 mL	3.1444 mL	7.8609 mL
	15 mM	0.2096 mL	1.0481 mL	2.0962 mL	5.2406 mL
	20 mM	0.1572 mL	0.7861 mL	1.5722 mL	3.9304 mL
	25 mM	0.1258 mL	0.6289 mL	1.2577 mL	3.1444 mL
	30 mM	0.1048 mL	0.5241 mL	1.0481 mL	2.6203 mL
	40 mM	0.0786 mL	0.3930 mL	0.7861 mL	1.9652 mL
	50 mM	0.0629 mL	0.3144 mL	0.6289 mL	1.5722 mL
	60 mM	0.0524 mL	0.2620 mL	0.5241 mL	1.3101 mL
	80 mM	0.0393 mL	0.1965 mL	0.3930 mL	0.9826 mL
	100 mM	0.0314 mL	0.1572 mL	0.3144 mL	0.7861 mL

Keywords

p,p'-DDE

2 Cited Publications

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p,p'-DDE

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Publications Citing Use of MedChemExpress (MCE) p,p'-DDE

Biologische Aktivität

Chemical Information

Publications (2)

Lösungsmittel & Löslichkeit

Reinheit & Dokumentation

Verweise

Help & FAQs

Complete Stock Solution Preparation Table

p,p'-DDE

Metabolism/Protease Compound Library

Anti-diabetic Compound Library

Endocrinology Compound Library

Orally Active Compound Library

Transcription Factor-Targeted Library

Drug Metabolite Library

Tumorigenesis-Related Compound Library

Human Metabolite Library

Anti-Prostate Cancer Compound Library

Nuclear Receptor Compound Library

Mitochondrial Toxicity Compound Library

Bioactive Compound Library Max

MCE Bioactive Compound Library

Bioactive Compound Library

High-Throughput Bioactive Compound Library

Mass Spectrometry Human Metabolite Library

Environmental Pollutant Compound Library

Publications Citing Use of MedChemExpress (MCE) p,p'-DDE

Biologische Aktivität

Chemical Information

Publications (2)

Lösungsmittel & Löslichkeit

Reinheit & Dokumentation

Verweise

Help & FAQs

Complete Stock Solution Preparation Table

p,p'-DDE Related Classifications

HY-B1986 Related Classifications