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Art. -Nr.: HY-169993A

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Pevifoscorvir

Name: Pevifoscorvir
Brand: MedChemExpress
SKU: HY-169993A
Availability: PreOrder

(Synonyms: ALG-000184 free acid)

Pevifoscorvir (ALG-000184 (free acid)) is an orally active inhibitor of hepatitis B virus (HBV), and it is also a prodrug of ALG-001075 (HY-177022). Pevifoscorvir can inhibit the production of HBV DNA in liver cells. Pevifoscorvir can be used in the research of chronic hepatitis B.

Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.

CAS. Nr.: 2495324-71-3
Formel: C₂₃H₂₂FN₄O₈P
Molecular Weight:532.41

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (284 KB)

Pevifoscorvir Chemical Structure

CAS. Nr.: 2495324-71-3

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Other In-stock Forms of Pevifoscorvir

Pevifoscorvir sodium

Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- In Vitro
- In Vivo
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

Alle DNA/RNA Synthesis Isoform-spezifische Produkte anzeigen :

In Vitro

Viral Infection

Pevifoscorvir (ALG-000184 (free acid)) (3 days) potently inhibits HBV DNA production in HepG2.117 cells, with an EC₅₀ of 1.45 nM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Pevifoscorvir (ALG-000184 (free acid)) (10-30 mg/kg; p.o.; single dose) is completely converted to ALG-001075 following oral administration in rats and dogs, resulting in high exposure of ALG-001075 in the liver, and the systemic exposure of ALG-001075 is 50 or 12-fold higher than that achieved by direct administration of ALG-001075^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS. Nr. 2495324-71-3
Molecular Weight 532.41
Formel C₂₃H₂₂FN₄O₈P
SMILES

N#CC1=CC(NC(C2=C(C)C(C(C(N(C3(COC3)C#C)COP(O)(O)=O)=O)=O)=C(C)N2C)=O)=CC=C1F
Synonyms

ALG-000184 free acid
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (284 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Sandrine Vendeville, et al. The Discovery and Preclinical Profile of ALG-000184, a Prodrug of the Potent Hepatitis B Virus Capsid Assembly Modulator ALG-001075. J Med Chem. 2024 Dec 12;67(23):21126-21142. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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