Polymyxin A2
Polymyxin A2 is a heteropeptide antibiotic found in different strains of Bacillus polymyxa, and its effect against Gram-negative bacteria is greater than that against Gram-positive bacteria.
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- CAS. Nr.: 65454-51-5
- Formel: C50H94N16O14
- Molecular Weight:1143.38
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
Beschreibung
Chemical Information
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CAS. Nr. 65454-51-5
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Molecular Weight 1143.38
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Formel C50H94N16O14
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SMILES
CC(CCCCC(N[C@H](C(N[C@H](C(N[C@@H](C(N[C@H](C(N[C@H]1CCN)=O)CCNC([C@@H](NC([C@@H](NC([C@H](CCN)NC([C@H]([C@H](O)C)NC([C@H](NC1=O)CC(C)C)=O)=O)=O)CCN)=O)[C@H](C)O)=O)=O)CCN)=O)[C@H](C)O)=O)CCN)=O)C
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Structure Classification
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Initial Source
Paenibacillus polymyxa
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Protokoll
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Gram Staining of Tissue Sections
Gram staining of tissue sections is a histochemical technique used to differentiate Gram-positive and Gram-negative bacteria within histological specimens based on differences in bacterial cell wall structure and dye retention, adapted from classical bacteriological Gram staining into tissue-compatible “histological Gram stain” variants. In tissue applications, modifications of the Brown-Hopps and Brown-Brenn methods are commonly used to improve differentiation of microorganisms embedded within host connective tissue and to reduce overstaining or loss of Gram-negative signal, which are known limitations of earlier approaches. The principle relies on crystal violet-iodine complex retention in Gram-positive organisms and subsequent decolorization and counterstaining steps that allow contrast visualization of Gram-negative organisms against tissue background.
Reinheit & Dokumentation
Verweise
[1]. Sandra Mikhail, et al. Evaluation of the Synergy of Ceftazidime-Avibactam in Combination with Meropenem, Amikacin, Aztreonam, Colistin, or Fosfomycin against Well-Characterized Multidrug-Resistant Klebsiella pneumoniae and Pseudomonas aeruginosa. Antimicrob Agents Chemother. 2019 Jul 25;63(8):e00779-19. [Content Brief]
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)