Leptin
Leptin is a 16-kDa adipocyte-derived hormone of the long-chain helical cytokine family whose plasma levels track body fat stores. Discovered through the obese ob/ob mouse, leptin conveys an adiposity signal to the arcuate nucleus: it binds the long leptin receptor isoform, activates JAK2/STAT3 signaling and stimulates POMC/CART neurons while inhibiting NPY/AgRP cells, suppressing appetite and raising energy expenditure. Leptin also gates the hypothalamic-pituitary-gonadal and thyroid axes, links starvation to infertility, and modulates immune responses. Most human obesity features leptin resistance rather than deficiency, although rare LEP mutations cause severe early-onset obesity that responds dramatically to recombinant leptin (metreleptin) therapy.
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Leptin Recombinant Proteins (7)
- Species:
- Source:
Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
- Formel: Human
- Molecular Weight: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
