STKR
STKR denotes the serine/threonine kinase receptor family of the TKL group — the TGF-beta superfamily type I and type II receptors such as TGFBR1/2, ACVR1, BMPR1/2, and ACVRL1. Type II receptors bind ligands (TGF-betas, BMPs, activins) and phosphorylate the GS box of type I receptors, whose activated kinases then phosphorylate SMAD1/5 or SMAD2/3 to control proliferation, differentiation, immunity, and development. Mutations cause hereditary hemorrhagic telangiectasia (ACVRL1, ACVR1), pulmonary arterial hypertension (BMPR2), and Marfan-like syndromes, while TGF-beta receptor signaling is a major fibrosis and immuno-oncology target. Recombinant STKR ectodomains and kinase domains serve these programs.
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STKR Recombinant Proteins (18)
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Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
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- Formel: Human
- Molecular Weight: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
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