Psammaplysene A
Based on 1 Customer Validation
Psammaplysene A, a brominated tyrosine derivative, can promote the nuclear localization of FOXO1, leading to cell cycle arrest and apoptosis, and can be used in cancer research.
Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.
- Reinheit : 99.72%
- CAS. Nr.: 850013-02-4
- Formel: C27H35Br4N3O3
- Molecular Weight:769.20
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Speicherung:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biologische Aktivität
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Chemical Information
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Lösungsmittel & Löslichkeit
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
Biologische Aktivität
Beschreibung
In Vitro
Psammaplysene A (1-1000 nM, 24 h) can induce apoptosis of endometrial cancer cells Ishikawa and ECC1, and affect cell viability and cycle distribution[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Ishikawa and ECC1 cells
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Concentration:1 nM, 10 nM, 100 nM and 1 μM
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Incubation Time:24 h
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Result:Increased nuclear FOXO1 protein levels in both cell lines at a concentration of 1 μM.
Did not significantly affect cell viability at a concentration of 100 nM, but significantly reduced the number of viable cells by approximately 5-fold at 1 μM.
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Cell Line:Ishikawa and ECC1 cells
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Concentration:100 nM, 500 nM, and 1 μM
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Incubation Time:24 h
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Result:Significantly increased the percentage of cells in G2/M phase in both cell lines at 1 μM.
Chemical Information
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CAS. Nr. 850013-02-4
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Appearance Solid
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Molecular Weight 769.20
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Formel C27H35Br4N3O3
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Color White to off-white
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SMILES
O=C(NCCCOC1=C(Br)C=C(CCN(C)C)C=C1Br)/C=C/C2=CC(Br)=C(OCCCN(C)C)C(Br)=C2
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Structure Classification
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Initial Source
Psammaplysilla sp.
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Lösungsmittel & Löslichkeit
In Vitro:
DMSO : 25 mg/mL (32.50 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
In Vivo:
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL.
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Reinheit & Dokumentation
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Data Sheet (273 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
Verweise
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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| DMSO | 1 mM | 1.3001 mL | 6.5003 mL | 13.0005 mL | 32.5013 mL |
| 5 mM | 0.2600 mL | 1.3001 mL | 2.6001 mL | 6.5003 mL | |
| 10 mM | 0.1300 mL | 0.6500 mL | 1.3001 mL | 3.2501 mL | |
| 15 mM | 0.0867 mL | 0.4334 mL | 0.8667 mL | 2.1668 mL | |
| 20 mM | 0.0650 mL | 0.3250 mL | 0.6500 mL | 1.6251 mL | |
| 25 mM | 0.0520 mL | 0.2600 mL | 0.5200 mL | 1.3001 mL | |
| 30 mM | 0.0433 mL | 0.2167 mL | 0.4334 mL | 1.0834 mL |
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