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Art. -Nr.: HY-121723

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PU-H39

PU-H39 is a selective Grp94 inhibitor with an IC₅₀ of 0.12 μM. PU-H39 can be used for the research of breast cancer.

Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.

CAS. Nr.: 852030-38-7
Formel: C₁₆H₁₃Cl₂N₅S
Molecular Weight:378.28

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

PU-H39 Chemical Structure

CAS. Nr.: 852030-38-7

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- Cellular Effect
- In Vitro
Chemical Information
Protokoll (1)
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

PU-H39 is a selective Grp94 inhibitor with an IC₅₀ of 0.12 μM. PU-H39 can be used for the research of breast cancer^[1].

Alle HSP Isoform-spezifische Produkte anzeigen :

Cellular Effect

Cell Line	Type	Value	Description	References
SK-BR-3	IC₅₀	>500 μM Compound: 11l	Inhibitory concentration against SKBr3 cell line Inhibitory concentration against SKBr3 cell line	[PMID: 15828828]
SK-BR-3	IC₅₀	500 μM Compound: 11l	Inhibitory concentration against SKBr3 cell line Inhibitory concentration against SKBr3 cell line	[PMID: 15828828]

In Vitro

PU-H39 (compound 9g) shows minimal off-target binding to kinases at 10 μM, exhibiting 34% and 32% inhibition of MKNK2 and ROCK2 kinases respectively^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.

Chemical Information

CAS. Nr. 852030-38-7
Molecular Weight 378.28
Formel C₁₆H₁₃Cl₂N₅S
SMILES

ClC1=CC=C(SC2=NC=3C(=NC=NC3N2CCCC#C)N)C(Cl)=C1
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Protokoll

All Animals and Diseases

Breast Cancer Modeling
Breast cancer is a heterogeneous cancer, and it has been distinguished into four subtypes: luminal A, luminal B, HER2-positive and basal-like. Molecular mutations, epigenetic alterations, hormone exposure and immune microenvironment are related to the progression of breast cancer.

Reinheit & Dokumentation

Handling Instructions (2659 KB)

Verweise

[1]. Patel HJ, et al. Structure-activity relationship in a purine-scaffold compound series with selectivity for the endoplasmic reticulum Hsp90 paralog Grp94. J Med Chem. 2015;58(9):3922-3943. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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