RAF-IN-4
RAF-IN-4 (Compound 120) is a Raf Kinase inhibitor. RAF-IN-4 shows IC50 values of 134.3, 118.6 and 276.7 nM for B-Raf, B-Raf (V600E) and C-Raf. RAF-IN-4 can inhibit the proliferation of cancer cells by blocking the Raf signaling pathway. RAF-IN-4 can be used for research of cancer, such as lung cancer and breast cancer.
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- CAS. Nr.: 1445582-05-7
- Formel: C23H18N4O2S
- Molecular Weight:414.48
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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Chemical Information
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Help & FAQs
Biologische Aktivität
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B-Raf 134.3 nM (IC50) |
BRafV600E 118.6 nM (IC50) |
C-Raf 276.7 nM (IC50) |
RAF-IN-4 inhibits A549, A375, MDA-MB-231 and COLO2OS cells proliferation with IC50 values of 12.1, 8.5, 10.9 and 7.3 μM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS. Nr. 1445582-05-7
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Molecular Weight 414.48
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Formel C23H18N4O2S
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SMILES
O=S(=O)(C=1C=CC(=CC1)C2=CC=C3N=CC=C(NC=4C=CC=C5NN=CC54)C3=C2)C
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
RAF-IN-4 Related Classifications
HY-177946 Related Classifications
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