Reversin 121
Based on 1 Customer Validation
Reversin 121 is a P-glycoprotein inhibitor. Reversin 121 increases the ATPase activity of MDR1. Reversin 121 reverses P-glycoprotein-mediated multidrug resistance. Reversin 121 can be used in the research of cancers.
Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.
- Reinheit: 99.08%
- CAS. Nr.: 174630-04-7
- Formel: C34H47N3O9
- Molecular Weight:641.75
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Speicherung:
Sealed storage, away from moisture and light, under nitrogen.
Pure form -80°C, 2 years , -20°C, 1 year* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biologische Aktivität
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Chemical Information
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Lösungsmittel & Löslichkeit
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
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Membrane Transporter/Ion Channel Compound Library
HY-L011
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Anti-Cancer Compound Library
HY-L025
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Peptide Library
HY-L105
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Cancer Stem Cells Compound Library
HY-L135
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Anti-Drug-Resistant Compound Library
HY-L169
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Anti-Ovarian Cancer Compound Library
HY-L173
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Bioactive Compound Library Max
HY-L181
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MCE Bioactive Compound Library
HY-L001V
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Peptide Compound Library
HY-L105S
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Bioactive Compound Library
HY-L001
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High-Throughput Bioactive Compound Library
HY-L205
Biologische Aktivität
P-glycoprotein[1]
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| NIH3T3 | IC50 |
1.41 μM
Compound: 1
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Inhibition of human MDR1 expressed in mouse NIH3T3 cells assessed as inhibition of drug efflux by flow cytometry
Inhibition of human MDR1 expressed in mouse NIH3T3 cells assessed as inhibition of drug efflux by flow cytometry
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[PMID: 20731360] |
Reversin 121 (12 μg/mL) (with gemcitabine (HY-17026)) reduces the proportions of tumor cells positive for MDR proteins in Panc1 cell[1].
Reversin 121 (5 μM) reverses the resistance against paclitaxel in paclitaxel-resistant NCI-H460 cell[2].
Reversin 121 (10 μM, 48 h) inhibits T cell proliferation[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Orthotopic pancreatic carcinoma mouse model[1].
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Dosage:2.5 mg/kg, plus 5-fluorouracil, 35 mg/kg/day
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Administration:Intraperitoneal injection (i.p.), 5 days a week
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Result:Decreased in MRP3-positive cells.
Chemical Information
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CAS. Nr. 174630-04-7
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Appearance Oil
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Molecular Weight 641.75
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Formel C34H47N3O9
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Color Colorless to light yellow
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Sealed storage, away from moisture and light, under nitrogen
Pure form -80°C 2 years -20°C 1 year * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen)
Lösungsmittel & Löslichkeit
DMSO : 100 mg/mL (155.82 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Reinheit & Dokumentation
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Data Sheet (272 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
Verweise
[1]. Hoffmann K, et al. Effects of the high-affinity Peptide reversin 121 on multidrug resistance proteins in experimental pancreatic cancer. Tumour Biol. 2008;29(6):351-8. [Content Brief]
[2]. Yabuki N, et al. Gene amplification and expression in lung cancer cells with acquired paclitaxel resistance. Cancer Genet Cytogenet. 2007 Feb;173(1):1-9. [Content Brief]
[3]. Kooij G, et al. P-glycoprotein acts as an immunomodulator during neuroinflammation. PLoS One. 2009 Dec 8;4(12):e8212. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.5582 mL | 7.7912 mL | 15.5824 mL | 38.9560 mL |
| 5 mM | 0.3116 mL | 1.5582 mL | 3.1165 mL | 7.7912 mL | |
| 10 mM | 0.1558 mL | 0.7791 mL | 1.5582 mL | 3.8956 mL | |
| 15 mM | 0.1039 mL | 0.5194 mL | 1.0388 mL | 2.5971 mL | |
| 20 mM | 0.0779 mL | 0.3896 mL | 0.7791 mL | 1.9478 mL | |
| 25 mM | 0.0623 mL | 0.3116 mL | 0.6233 mL | 1.5582 mL | |
| 30 mM | 0.0519 mL | 0.2597 mL | 0.5194 mL | 1.2985 mL | |
| 40 mM | 0.0390 mL | 0.1948 mL | 0.3896 mL | 0.9739 mL | |
| 50 mM | 0.0312 mL | 0.1558 mL | 0.3116 mL | 0.7791 mL | |
| 60 mM | 0.0260 mL | 0.1299 mL | 0.2597 mL | 0.6493 mL | |
| 80 mM | 0.0195 mL | 0.0974 mL | 0.1948 mL | 0.4869 mL | |
| 100 mM | 0.0156 mL | 0.0779 mL | 0.1558 mL | 0.3896 mL |
Reversin 121 Related Classifications
HY-125486 Related Classifications
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