Sennoside C
Based on 1 Customer Validation
Sennoside C is an orally active component of the traditional Chinese medicine Sennae Folium. Sennoside C can bind to human lysozyme and inhibit its amyloid fibrosis (IC50: 186.20 μM). Sennoside C has certain purgative activity. Sennoside C can be used in the research of diarrhea and anti-amyloid related diseases.
Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.
- Reinheit: 99.63%
- CAS. Nr.: 37271-16-2
- Formel: C42H40O19
- Molecular Weight:848.76
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Speicherung:
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
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Biologische Aktivität
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Chemical Information
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Lösungsmittel & Löslichkeit
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
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Natural Product Library
HY-L021
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Phenols Library
HY-L057
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Orally Active Compound Library
HY-L061
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Traditional Chinese Medicine Active Compound Library
HY-L065
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Plant-Sourced Natural Product Library
HY-L115
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Bioactive Compound Library Max
HY-L181
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MCE Bioactive Compound Library
HY-L001V
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Natural Product Library Plus
HY-L021P
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Natural Product and Natural Product-Like Compound Library
HY-L021M
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Bioactive Compound Library
HY-L001
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PBCRBS Traditional Chinese Medicine Compound Library
HY-L193
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Heat-Clearing and Detoxification Traditional Chinese Medicine Compound Library
HY-L194
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High-Throughput Bioactive Compound Library
HY-L205
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High-Throughput Natural Product Library
HY-L206
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Ancient Chinese Classical Formulas Traditional Chinese Medicine Active Compound Library
HY-L209
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Diarrhea-Related Traditional Chinese Medicine Active Compound Library
HY-L224
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Mongolian Medicine Compound Library
HY-L238
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Quinones Library
HY-L243
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Natural Product Diversity Scaffold Library
HY-L245
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Mass Spectrometry Natural Product Library
HY-L262
Biologische Aktivität
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Mice[3]
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Dosage:/
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Administration:oral administration
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Result:Had an ED50 of 11.2 mg/kg for purgative activity.
Was as active as Sennoside A, and when it accounts for 20% of the mixture, it exerted a potentiating effect of about 1.6 on the purgative activity of Sennoside A.
Chemical Information
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CAS. Nr. 37271-16-2
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Appearance Solid
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Molecular Weight 848.76
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Formel C42H40O19
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Color White to yellow
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SMILES
OC(C(O)C1O)C(OC1CO)OC2=CC=CC(C(C(C3=CC(CO)=CC(O)=C3C4=O)C5=C4C(OC(C(C(O)C6O)O)OC6CO)=CC=C5)C7=CC(C(O)=O)=CC(O)=C87)=C2C8=O
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Structure Classification
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Initial Source
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
Lösungsmittel & Löslichkeit
DMSO : 25 mg/mL (29.45 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Reinheit & Dokumentation
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Data Sheet (279 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
Verweise
[1]. Rama Reddy NR, et al. Next Generation Sequencing and Transcriptome Analysis Predicts Biosynthetic Pathway of Sennosides from Senna (Cassia angustifolia Vahl.), a Non-Model Plant with Potent Laxative Properties. PLoS One. 2015 Jun 22;10(6):e0129422. [Content Brief]
[2]. Gao W, et al. Inhibition behavior of Sennoside A and Sennoside C on amyloid fibrillation of human lysozyme and its possible mechanism. Int J Biol Macromol. 2021 May 1;178:424-433. [Content Brief]
[3]. Kisa K, et al. Potentiating effect of sennoside C on purgative activity of sennoside A in mice. Planta Med. 1981 Jul;42(3):302-3. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.1782 mL | 5.8909 mL | 11.7819 mL | 29.4547 mL |
| 5 mM | 0.2356 mL | 1.1782 mL | 2.3564 mL | 5.8909 mL | |
| 10 mM | 0.1178 mL | 0.5891 mL | 1.1782 mL | 2.9455 mL | |
| 15 mM | 0.0785 mL | 0.3927 mL | 0.7855 mL | 1.9636 mL | |
| 20 mM | 0.0589 mL | 0.2945 mL | 0.5891 mL | 1.4727 mL | |
| 25 mM | 0.0471 mL | 0.2356 mL | 0.4713 mL | 1.1782 mL |
Sennoside C Related Classifications
HY-N1972 Related Classifications
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