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Art. -Nr.: HY-148273R

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Setidegrasib (Standard)

Name: Setidegrasib (Standard)
Brand: MedChemExpress
SKU: HY-148273R
Availability: PreOrder

(Synonyms: ASP-3082 (Standard); KRAS G12D inhibitor 17 (Standard))

Setidegrasib (Standard) is the analytical standard of Setidegrasib (HY-148273). This product is intended for research and analytical applications. Setidegrasib (ASP-3082) is a PROTAC KRAS degrader (DC₅₀: 37 nM). Setidegrasib induces the degradation of G12D-mutation KRAS protein. Setidegrasib suppresses p-ERK, p-AKT, p-S6 levels in AsPC-1 cells. Setidegrasib exhibits anti-tumor activity in various cancer xenograft models in mice. Setidegrasib can be used in studies involving KRAS(G12D)-mutated solid tumors, such as non-small cell lung cancer.

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CAS. Nr.: 2821793-99-9
Formel: C₆₀H₆₅FN₁₂O₇S
Molecular Weight:1117.30

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Setidegrasib (Standard) Chemical Structure

CAS. Nr.: 2821793-99-9

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Information

Anwendung

The compound is the grade of analytical standard, which is the reference standard supplied assay. It is commonly used in qualitative, quantitative and methodological research experiments in HPLC, GC and MS.

Chemical Information

CAS. Nr. 2821793-99-9
Molecular Weight 1117.30
Formel C₆₀H₆₅FN₁₂O₇S
SMILES

CC1=C(SC=N1)C2=CC=C(C=C2)[C@@H](NC([C@@H]3C[C@H](CN3C([C@H](C(C)C)N4C=C(N=N4)C5=CC=C(C=C5)COC6=[C@]([C@]7=C(C(F)=CC8=C7C=NN8)C)C(C9CC9)=CC%10=C6N=C(N=C%10N%11C[C@@H]%12C[C@H]%11CN%12)OC%13CCOCC%13)=O)O)=O)CO
Synonyms

ASP-3082 (Standard); KRAS G12D inhibitor 17 (Standard)
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

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MOQ

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100 mg

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Setidegrasib (Standard)

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Chemical Information

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Setidegrasib (Standard) Related Classifications

HY-148273R Related Classifications

Bioz

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