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Art. -Nr.: HY-130558

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SL-1-73

SL-1-73 is a tubulin ligand. SL-1-73 exhibits antitumor activity against esophageal squamous cell carcinoma (ESCC) both in vitro and in vivo by inhibiting microtubule assembly, inducing G2/M phase cell cycle arrest and apoptosis, and disrupting tumor blood vessels. SL-1-73 can be used for the research of ESCC and other tumors.

Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.

CAS. Nr.: 2000199-44-8
Formel: C₂₀H₁₉N₃O₅S
Molecular Weight:413.45

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (269 KB)

SL-1-73 Chemical Structure

CAS. Nr.: 2000199-44-8

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- Cellular Effect
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

Cellular Effect

Cell Line	Type	Value	Description	References
Bel-7402	IC₅₀	1.83 μM Compound: 13k	Antiproliferative activity against human Bel7402 assessed as reduction in cell viability measured after 48 hrs by SRB assay Antiproliferative activity against human Bel7402 assessed as reduction in cell viability measured after 48 hrs by SRB assay	[PMID: 27919655]
HepG2	IC₅₀	0.096 μM Compound: 13k	Antiproliferative activity against human HepG2 assessed as reduction in cell viability measured after 48 hrs by SRB assay Antiproliferative activity against human HepG2 assessed as reduction in cell viability measured after 48 hrs by SRB assay	[PMID: 27919655]
KYSE-140	IC₅₀	0.01 μM Compound: 12c	Antiproliferative activity against human KYSE-140 cells assessed as cell growth inhibition measured after 48 hrs by CCK-8 assay Antiproliferative activity against human KYSE-140 cells assessed as cell growth inhibition measured after 48 hrs by CCK-8 assay	[PMID: 34838335]
KYSE-30	IC₅₀	0.01 μM Compound: 12c	Antiproliferative activity against human KYSE-30 cells assessed as cell growth inhibition measured after 48 hrs by CCK-8 assay Antiproliferative activity against human KYSE-30 cells assessed as cell growth inhibition measured after 48 hrs by CCK-8 assay	[PMID: 34838335]
KYSE-410	IC₅₀	0.01 μM Compound: 12c	Antiproliferative activity against human KYSE-410 cells assessed as cell growth inhibition measured after 48 hrs by CCK-8 assay Antiproliferative activity against human KYSE-410 cells assessed as cell growth inhibition measured after 48 hrs by CCK-8 assay	[PMID: 34838335]
KYSE-510	IC₅₀	0.01 μM Compound: 12c	Antiproliferative activity against human KYSE-510 cells assessed as cell growth inhibition measured after 48 hrs by CCK-8 assay Antiproliferative activity against human KYSE-510 cells assessed as cell growth inhibition measured after 48 hrs by CCK-8 assay	[PMID: 34838335]
MCF7	IC₅₀	0.45 μM Compound: 13k	Antiproliferative activity against human MCF7 assessed as reduction in cell viability measured after 48 hrs by SRB assay Antiproliferative activity against human MCF7 assessed as reduction in cell viability measured after 48 hrs by SRB assay	[PMID: 27919655]
MIA PaCa-2	IC₅₀	0.43 μM Compound: 13k	Antiproliferative activity against human MIAPaCa2 assessed as reduction in cell viability measured after 48 hrs by SRB assay Antiproliferative activity against human MIAPaCa2 assessed as reduction in cell viability measured after 48 hrs by SRB assay	[PMID: 27919655]

Chemical Information

CAS. Nr. 2000199-44-8
Molecular Weight 413.45
Formel C₂₀H₁₉N₃O₅S
SMILES

O=S(NC1=CC=C(OC)N=C1OC)(C2=CC(C3=CC(O)=CC=C3N4C)=C4C=C2)=O
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (269 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Niu F, et al. Novel carbazole sulfonamide microtubule-destabilizing agents exert potent antitumor activity against esophageal squamous cell carcinoma. Cancer Lett. 2018 Apr 28;420:60-71. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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