SMI-1074
SMI-1074, a SMARCA bromodomain inhibitor, is a PROTAC target protein ligand (Ligand for Target Protein for PROTAC). SMI-1074 can be used for synthesis SMD-3236 (HY-170824) and SMD-1087 (HY-170828). SMI-1074 can be used for the research of smarca4-deficient cancers.
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- CAS. Nr.: 3033592-13-8
- Formel: C25H26ClN3O
- Molecular Weight:419.95
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biologische Aktivität
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Chemical Information
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
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Biologische Aktivität
Beschreibung
IC50 & Target
[1]|
SMARCA2 66 nM (IC50) |
SMARCA4 83 nM (IC50) |
In Vitro
SMI-1074 binds to purified human SMARCA2 and SMARCA4 bromodomains with IC50 values of 66 nM and 83 nM, respectively[1].
SMI-1074 (10 μM; 2 h) pretreatment of HeLa cells blocks SMD-3236-induced degradation of SMARCA2[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS. Nr. 3033592-13-8
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Molecular Weight 419.95
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Formel C25H26ClN3O
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SMILES
ClC1=CC=CC(N2C(C3(C4=C2C=C(C=C4)C5CCNCC5)CCCCC3)=N6)=C1C6=O
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
[1]. Yang L, et al. Discovery of SMD-3236: A Potent, Highly Selective and Efficacious SMARCA2 Degrader for the Treatment of SMARC4-Deficient Human Cancers. J Med Chem. 2025;68(2):1155-1178. [Content Brief]
[2]. Leng L, et al. Discovery of High-Affinity SMARCA2/4 Bromodomain Ligands and Development of Potent and Exceptionally Selective SMARCA2 PROTAC Degraders. J Med Chem. 2025;68(2):1113-1133. [Content Brief]
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
SMI-1074 Related Classifications
HY-170817 Related Classifications
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Keywords
- SMI-1074
- 3033592-13-8
- SMI1074
- SMI 1074
- Ligands for Target Protein for PROTAC
- SWI/SNF Complex
- Target Protein-binding Moiety
- SWI/SNF Family of Chromatin-Remodelling Complexes
- SMARCA bromodomain
- SMARCA4 bromodomain
- recombinant human SMARCA2 bromodomain
- recombinant human SMARCA4 bromodomain
- SMARCA2 bromodomain
- HeLa cells
- smarca4-deficient human cancers
- Inhibitor
- inhibitor
- inhibit