Art. -Nr.: HY-150538

STAT3-IN-12

1 Cited Publications

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STAT3-IN-12 is a potent STAT3 signal inhibitor that can inhibit IL-6 induced JAK/STAT3 signalling pathway activation. STAT3-IN-12 inhibits cancer cell growth, migration, and induce cell apoptosis as well as cycle arrest. STAT3-IN-12 can be used in cancer-related research, such as hepatocellular carcinoma (HCC) and oesophageal carcinoma.

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Reinheit: 99.87%
CAS. Nr.: 2980758-31-2
Formel: C₂₈H₃₀N₄O₂
Molecular Weight:454.56

Speicherung:

Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month

STAT3-IN-12 Chemical Structure

CAS. Nr.: 2980758-31-2

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Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- Cellular Effect
- In Vitro
- In Vivo
Chemical Information
Publications (1)
Lösungsmittel & Löslichkeit
- In Vitro
Reinheit & Dokumentation
Verweise
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

IC₅₀ & Target^[1]

STAT3

Alle STAT Isoform-spezifische Produkte anzeigen :

Cellular Effect

Cell Line	Type	Value	Description	References
ECa-109 cell line	IC₅₀	3.63 μM Compound: 24	Antitumor activity against human EC109 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay Antitumor activity against human EC109 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay	[PMID: 35504209]
HepG2	IC₅₀	4.3 μM Compound: 24	Antitumor activity against human HepG2 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay Antitumor activity against human HepG2 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay	[PMID: 35504209]

In Vitro

STAT3-IN-12 (compound 24, 0-10 μM approximately, 72 h) inhibits cancer cell growth and migration in HepG2 and EC109 cells^[1].
STAT3-IN-12 (0-20 μM, 16 h) binds to the STAT3 protein and inhibits IL-6-mediated STAT3 phosphorylation, also inhibts STAT3 nuclear localization and dimerization in EC109 and HepG2 cells^[1].
STAT3-IN-12 (0-20 μM, 48 h) induces cell apoptosis as well as cycle arrest in HepG2 and EC109 cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[1]

Cell Line:

HepG2 and EC109 cells
Concentration:

0, 1.25, 2.5, 5 and 10 μM.
Incubation Time:

72 h
Result:

Inhibited cancer cell growth with IC₅₀ values of 4.32 and 3.63 μM.

Cell Migration Assay ^[1]

Cell Line:

HepG2 and EC109 cells
Concentration:

0-10 μM
Incubation Time:

24 h
Result:

Inhibited cancer cell migration.

Western Blot Analysis^[1]

Cell Line:

HepG2 and EC109 cells
Concentration:

0, 2.5, 5, 10 and 20 μM
Incubation Time:

16 h
Result:

Inhibited phosphorylation of STAT3 tyrosine 705 with high selectivity.

In Vivo

STAT3-IN-12 (compound 24, intraperitoneal injection, 20, 40 mg/kg, daily for 24 days) displays obvious antitumor activity in a mouse HepG2 cell xenograft tumor model without no obvious toxicity^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

HepG2 cell xenograft tumor model^[1]
Dosage:

20, 40 mg/kg, daily for 24 days
Administration:

Intraperitoneal injection
Result:

Inhibited tumor growth without affecting the body weight.

Chemical Information

CAS. Nr. 2980758-31-2
Appearance Solid
Molecular Weight 454.56
Formel C₂₈H₃₀N₄O₂
Color Off-white to light yellow
SMILES

CCCN1C2=C(C=C3C(N(CCC)C(C4=CC=CC(OC)=C4)=N3)=C2)N=C1C5=CC=CC(OC)=C5
Versand

Room temperature in continental US; may vary elsewhere.

Speicherung

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Publications (1)

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Neurotherapeutics

Reticuline modulates astrocyte and microglial responses to enhance prognosis after traumatic brain injury. [Abstract]

2025 Aug 5:e00709. PMID: 40769849

Lösungsmittel & Löslichkeit

In Vitro:

DMSO : 100 mg/mL (219.99 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

2.1999 mL

10.9996 mL

21.9993 mL

5 mM

0.4400 mL

2.1999 mL

4.3999 mL

10 mM

0.2200 mL

1.1000 mL

2.1999 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (275 KB)
SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Yi-Chen Liu, et al. Benzobis(imidazole) derivatives as STAT3 signal inhibitors with antitumor activity. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	2.1999 mL	10.9996 mL	21.9993 mL	54.9982 mL
	5 mM	0.4400 mL	2.1999 mL	4.3999 mL	10.9996 mL
	10 mM	0.2200 mL	1.1000 mL	2.1999 mL	5.4998 mL
	15 mM	0.1467 mL	0.7333 mL	1.4666 mL	3.6665 mL
	20 mM	0.1100 mL	0.5500 mL	1.1000 mL	2.7499 mL
	25 mM	0.0880 mL	0.4400 mL	0.8800 mL	2.1999 mL
	30 mM	0.0733 mL	0.3667 mL	0.7333 mL	1.8333 mL
	40 mM	0.0550 mL	0.2750 mL	0.5500 mL	1.3750 mL
	50 mM	0.0440 mL	0.2200 mL	0.4400 mL	1.1000 mL
	60 mM	0.0367 mL	0.1833 mL	0.3667 mL	0.9166 mL
	80 mM	0.0275 mL	0.1375 mL	0.2750 mL	0.6875 mL
	100 mM	0.0220 mL	0.1100 mL	0.2200 mL	0.5500 mL

Keywords

STAT3-IN-12

1 Cited Publications

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STAT3-IN-12

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Publications Citing Use of MedChemExpress (MCE) STAT3-IN-12

Alle STAT Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Publications (1)

Lösungsmittel & Löslichkeit

Reinheit & Dokumentation

Verweise

Help & FAQs

Complete Stock Solution Preparation Table

STAT3-IN-12 Related Classifications

Art. -Nr.: HY-150538