Sterekunthal B
Sterekunthal B is a naphthoquinone compound and antimalarial agent. Sterekunthal B can be isolated from plants of the Bignoniaceae family, including the root bark of Stereospermum colais. Sterekunthal B inhibits the growth of Chloroquine (HY-17589A)-sensitive Plasmodium falciparum strain PoW with an IC50 of 23.3 μg/mL. Sterekunthal B also inhibits the growth of Chloroquine-resistant Plasmodium falciparum strain Dd2 with an IC50 of 15.2 μg/mL. Sterekunthal B exhibits non-selective cytotoxicity toward endothelial cells. Sterekunthal B can be used in malaria-related research.
Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.
- CAS. Nr.: 475673-78-0
- Formel: C20H18O4
- Molecular Weight:322.35
-
Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biologische Aktivität
-
Chemical Information
- Protokoll
- Reinheit & Dokumentation
- Verweise
-
Help & FAQs
Alle Parasite Isoform-spezifische Produkte anzeigen
More
Biologische Aktivität
Beschreibung
IC50 & Target
[1]|
Plasmodium |
In Vitro
Sterekunthal B inhibits growth of Plasmodium falciparum poW and Dd2 strains with IC50 values of 16-97 μM[1].
Sterekunthal B inhibits the growth of Chloroquine (HY-17589A)-sensitive Plasmodium falciparum PoW strain with an IC50 of 23.3 μg/mL and Chloroquine-resistant Plasmodium falciparum Dd2 strain with an IC50 of 15.2 μg/mL[2].
Sterekunthal B inhibits the proliferation of endothelial ECV-304 cells with an IC50 of 16.0 μg/mL[2].
Sterekunthal B exerts marked non-selective cytotoxicity against human endothelial (ECV-304) cells with an IC50 value of 16 µg/mL[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
-
CAS. Nr. 475673-78-0
-
Molecular Weight 322.35
-
Formel C20H18O4
-
SMILES
O=C[C@@]1([C@@]23C(C(C4=CC=CC=C4C3=O)=O)=C[C@@]5([H])[C@]1([H])CC[C@]5(O2)C)C
-
Structure Classification
-
Initial Source
-
Versand
Room temperature in continental US; may vary elsewhere.
-
Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
[1]. Malerich JP, et al. Biomimetic synthesis of antimalarial naphthoquinones. J Am Chem Soc. 2005 May 4;127(17):6276-83. [Content Brief]
[2]. Onegi B, et al. Antiplasmodial activity of naphthoquinones and one anthraquinone from Stereospermum kunthianum. Phytochemistry. 2002;60(1):39-44. [Content Brief]
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Sterekunthal B Related Classifications
HY-N20619 Related Classifications
Powered by Bioz