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Art. -Nr.: HY-N21964

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Sutherlandioside D

Sutherlandioside D is a natural product present in the aerial parts of Sutherlandia frutescens. Sutherlandioside D acts as an inhibitor of the Gli/hedgehog signaling pathway and exhibits reactive oxygen species (ROS) regulatory activity. Sutherlandioside D inhibits Gli reporter gene activity and reduces ROS production. Sutherlandioside D can be used in prostate cancer-related research.

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CAS. Nr.: 1055329-49-1
Formel: C₃₆H₅₈O₉
Molecular Weight:634.84

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Sutherlandioside D Chemical Structure

CAS. Nr.: 1055329-49-1

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- In Vitro
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

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In Vitro

Sutherlandioside D (0.1-10 μg/mL; 48 h) potently inhibits Gli-reporter activity in stimulated Shh Light II cells with an IC₅₀ of 1.8 μg/mL^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS. Nr. 1055329-49-1
Molecular Weight 634.84
Formel C₃₆H₅₈O₉
SMILES

O=C1[C@]23[C@@]4(C3)[C@]([C@H](C[C@@]2([H])C(C)(C=C1)C)O)([H])[C@]5([C@](CC4)([C@@](CC5)([H])[C@H](C)CC[C@H](O)C(C)(C)O[C@@H]6O[C@@H]([C@H]([C@@H]([C@H]6O)O)O)CO)C)C
Structure Classification
- Saccharides
- Monosaccharides
Initial Source
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Handling Instructions (2659 KB)

Verweise

[1]. Avula B, et al. Quantitative determination of flavonoids and cycloartanol glycosides from aerial parts of Sutherlandia frutescens (L.) R. BR. by using LC-UV/ELSD methods and confirmation by using LC-MS method. J Pharm Biomed Anal. 2010 Jun 5;52(2):173-80.

[2]. Lin H, et al. Inhibition of Gli/hedgehog signaling in prostate cancer cells by "cancer bush" Sutherlandia frutescens extract. Cell biology international. 2016 Feb;40(2):131-42.

[3]. Lei W, et al. Unveiling the anti-inflammatory activity of Sutherlandia frutescens using murine macrophages. International immunopharmacology. 2015 Dec;29(2):254-262.

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

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100 mg

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Biologische Aktivität
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- In Vitro
Chemical Information
Reinheit & Dokumentation
Verweise

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Sutherlandioside D

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