TMP920
Based on 1 Customer Validation
TMP920 is a highly potent and selective RORγt antagonist. TMP920 inhibits RORγt binding to the SRC1 peptide with an IC50 of 0.03 μM.
Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.
- Reinheit : 99.92%
- CAS. Nr.: 1421837-45-7
- Formel: C29H30N2O3
- Molecular Weight:454.56
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Speicherung:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biologische Aktivität
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Chemical Information
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Lösungsmittel & Löslichkeit
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
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HY-14422
SR1078RORα/RORγ Agonist -
HY-125801
3-Oxo-5β-cholanoic acidTH17 Cell Differentiation Inhibitor -
HY-14413
SR3335RORα Inverse Agonist -
HY-12776
GSK805RORγt Inhibitor -
HY-N2253
NeoruscogeninRORα Agoinst -
HY-101454
SR0987RORγt Agonist -
HY-104037
CintirorgonRORγ Agonist -
HY-16998
SR2211RORγ Inverse Agonist -
HY-19774
GNE-0946RORγ/RORc Agonist -
HY-120210
XY018ROR-γ Antagonist -
HY-132810
BevurogantRORγt Antagonist -
HY-19770
GSK2981278RORγ Inverse Agonist
Biologische Aktivität
Beschreibung
IC50 & Target
IC50: 0.03 μM (RORγt)[1]
In Vitro
TMP920 (0.09-30 μM) starts to show toxic effects on cell growth at >10 μM in Na?ve CD4+ T cells[1].
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TMP920 suppresses Th17 cell differentiation and lost its IL-17 inhibitory effect at <2.5 μM in vitro[1].
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TMP920 suppresses IL-17 production from differentiated Th17 cells in vitro[1].
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TMP920 suppresses the Th17 cell transcriptome and promotes alternate T-cell subsets[1].
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TMP920 significantly reduces RORγt-DNA interactions[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. .
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Cell Line:Naïve CD4 + T cells
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Concentration:0.09-30 μM
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Incubation Time:48 hours
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Result:Has toxic effects on cell growth at >10 μM.
Chemical Information
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CAS. Nr. 1421837-45-7
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Appearance Solid
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Molecular Weight 454.56
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Formel C29H30N2O3
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Color White to off-white
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SMILES
O=C(NC(C1=CC=C(C=C1C)C)C2=CC=CC=C2)CC3=CC=C(C=C3)OCC4=C(ON=C4C)C
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year
Lösungsmittel & Löslichkeit
In Vitro:
DMSO : 62.5 mg/mL (137.50 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Reinheit & Dokumentation
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Data Sheet (272 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
Verweise
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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| DMSO | 1 mM | 2.1999 mL | 10.9996 mL | 21.9993 mL | 54.9982 mL |
| 5 mM | 0.4400 mL | 2.1999 mL | 4.3999 mL | 10.9996 mL | |
| 10 mM | 0.2200 mL | 1.1000 mL | 2.1999 mL | 5.4998 mL | |
| 15 mM | 0.1467 mL | 0.7333 mL | 1.4666 mL | 3.6665 mL | |
| 20 mM | 0.1100 mL | 0.5500 mL | 1.1000 mL | 2.7499 mL | |
| 25 mM | 0.0880 mL | 0.4400 mL | 0.8800 mL | 2.1999 mL | |
| 30 mM | 0.0733 mL | 0.3667 mL | 0.7333 mL | 1.8333 mL | |
| 40 mM | 0.0550 mL | 0.2750 mL | 0.5500 mL | 1.3750 mL | |
| 50 mM | 0.0440 mL | 0.2200 mL | 0.4400 mL | 1.1000 mL | |
| 60 mM | 0.0367 mL | 0.1833 mL | 0.3667 mL | 0.9166 mL | |
| 80 mM | 0.0275 mL | 0.1375 mL | 0.2750 mL | 0.6875 mL | |
| 100 mM | 0.0220 mL | 0.1100 mL | 0.2200 mL | 0.5500 mL |
TMP920 Related Classifications
HY-117819 Related Classifications
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