Tocainide
Based on 1 Customer Validation
Tocainide hydrochloride is an orally activesodium channel blocker, it blocks the sodium channels in the pain-producing foci in the nerve membranes. Tocainide hydrochloride is a primary amine analog of lidocaine, can be used for the treatment of tinnitus.
Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.
- Reinheit: 99.06%
- CAS. Nr.: 41708-72-9
- Formel: C11H16N2O
- Molecular Weight:192.26
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Speicherung:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biologische Aktivität
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Chemical Information
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Lösungsmittel & Löslichkeit
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Membrane Transporter/Ion Channel Compound Library
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Sodium Channel Blocker Library
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Biologische Aktivität
IC50: sodium channel[1]
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS. Nr. 41708-72-9
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Appearance Solid
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Molecular Weight 192.26
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Formel C11H16N2O
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Color White to off-white
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SMILES
CC(N)C(NC1=C(C)C=CC=C1C)=O
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Lösungsmittel & Löslichkeit
DMSO : 125 mg/mL (650.16 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Reinheit & Dokumentation
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Data Sheet (273 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
Verweise
[1]. Alpert JS, et al. Chemistry, pharmacology, antiarrhythmic efficacy and adverse effects of tocainide hydrochloride, an orally active structural analog of lidocaine. Pharmacotherapy. 1983 Nov-Dec;3(6):316-23. [Content Brief]
[2]. De Luca A,et al.Optimal requirements for high affinity and use-dependent block of skeletal muscle sodium channel by N-benzyl analogs of tocainide-like compounds.Mol Pharmacol. 2003 Oct;64(4):932-45. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 5.2013 mL | 26.0065 mL | 52.0129 mL | 130.0323 mL |
| 5 mM | 1.0403 mL | 5.2013 mL | 10.4026 mL | 26.0065 mL | |
| 10 mM | 0.5201 mL | 2.6006 mL | 5.2013 mL | 13.0032 mL | |
| 15 mM | 0.3468 mL | 1.7338 mL | 3.4675 mL | 8.6688 mL | |
| 20 mM | 0.2601 mL | 1.3003 mL | 2.6006 mL | 6.5016 mL | |
| 25 mM | 0.2081 mL | 1.0403 mL | 2.0805 mL | 5.2013 mL | |
| 30 mM | 0.1734 mL | 0.8669 mL | 1.7338 mL | 4.3344 mL | |
| 40 mM | 0.1300 mL | 0.6502 mL | 1.3003 mL | 3.2508 mL | |
| 50 mM | 0.1040 mL | 0.5201 mL | 1.0403 mL | 2.6006 mL | |
| 60 mM | 0.0867 mL | 0.4334 mL | 0.8669 mL | 2.1672 mL | |
| 80 mM | 0.0650 mL | 0.3251 mL | 0.6502 mL | 1.6254 mL | |
| 100 mM | 0.0520 mL | 0.2601 mL | 0.5201 mL | 1.3003 mL |
Tocainide Related Classifications
HY-B1798 Related Classifications
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