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Art. -Nr.: HY-178047

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UM-242

UM-242 is a STING inhibitor, with an EC₅₀ of 1.70 μM in THP1-Dual cells expressing wild-type STING. UM-242 blocks STING oligomerization and inhibits diABZI-induced phosphorylation of TBK1 and IRF3, thereby suppressing the transcription of IFNβ and IL6 and reducing IFNβ secretion. UM-242 can be used for the study of STING-dependent inflammatory and neurological diseases.

Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.

Formel: C₂₄H₁₈F₂N₈O₅
Molecular Weight:536.45

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (271 KB)

UM-242 Chemical Structure

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Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- In Vitro
Chemical Information
Reinheit & Dokumentation
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Calculators
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Bioz

Biologische Aktivität

Beschreibung

Alle Interleukin Related Isoform-spezifische Produkte anzeigen :

In Vitro

UM-242 (0.2-5 μM, pretreated for 1 h) exerts potent inhibitory activity on diABZI-induced IFNβ and IL6 gene transcription in iBMDMs^[1].
UM-242 (2.5 μM, pretreated for 1 h) displays potent activity in blocking STING-dependent IFNβ secretion in primary human CD14⁺ monocytes^[1].
UM-242 (5 μM, pretreated for 1 h) shows potent inhibitory activity on diABZI-induced phosphorylation of TBK1 and IRF3and exhibits potent activity in inhibiting STING oligomerization in WT BMDMs, effectively blocking STING downstream signal transduction^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis^[1]

Cell Line:

WT BMDMs
Concentration:

5 μM
Incubation Time:

Pretreated for 1 h
Result:

Showed potent inhibitory activity on diABZI-induced phosphorylation of TBK1 and IRF3.
Exhibited potent activity in inhibiting STING oligomerization in WT BMDMs.

Chemical Information

Molecular Weight 536.45
Formel C₂₄H₁₈F₂N₈O₅
SMILES

O=C(C1=NOC(C2=CC(F)=CC=C2F)=N1)N[C@H](C3=NC4=CC=CC=C4N3)CCNC(C5=CC=C([N+]([O-])=O)O5)=N
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (271 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Barasa L, et al. Nitrofuran-Based STING Inhibitors. ACS Omega. 2025 Sep 4;10(36):41693-41706. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

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100 mg

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Biologische Aktivität
- Beschreibung
- In Vitro
Chemical Information
Reinheit & Dokumentation
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UM-242

Alle Interleukin Related Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Reinheit & Dokumentation

Verweise

Calculators

Help & FAQs

UM-242 Related Classifications

HY-178047 Related Classifications