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Art. -Nr.: HY-182618

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XAX-162

XAX-162 is a highly selective sphingosine 1-phosphate receptor 2 (S1PR2) agonist with a human EC₅₀ of 0.55 μM. XAX-162 does not activate other S1P receptors. XAX-162 exhibits noncompetitive inhibition of activity by S1PR2 antagonist JTE-013 (HY-100675).

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CAS. Nr.: 883053-48-3
Formel: C₁₆H₁₅NO₂S₃
Molecular Weight:349.49

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Please store the product under the recommended conditions in the Certificate of Analysis.

XAX-162 Chemical Structure

CAS. Nr.: 883053-48-3

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

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- In Vitro
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Beschreibung

IC₅₀ & Target

S1PR2

0.55 μM (EC₅₀)

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In Vitro

XAX-162 (0.55 μM) activates S1PR2 in S1PR2 CRE-bla CHO cells with an EC₅₀ of 0.55 μM, reaching a maximum activity 130% of that induced by 1 μM S1P^[1].
XAX-162-mediated receptor activation is inhibited by JTE-013 (HY-100675) in a noncompetitive manner, with reduced response magnitude and right-shifted dose-response curves as JTE-013 concentration increases in S1PR2 CRE-bla CHO cells^[1].
XAX-162 is highly selective for S1PR2, showing no agonist activity in cell-based assays for S1PR1, S1PR3, S1PR4, or S1PR5^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS. Nr. 883053-48-3
Molecular Weight 349.49
Formel C₁₆H₁₅NO₂S₃
SMILES

CC(C=C1)=CC=C1SC2=CC=C(C3SCCS3)C=C2[N+]([O-])=O
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Handling Instructions (2659 KB)

Verweise

[1]. Satsu H, et al. A sphingosine 1-phosphate receptor 2 selective allosteric agonist. Bioorg Med Chem. 2013;21(17):5373-5382. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

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How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Biologische Aktivität
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- In Vitro
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XAX-162

Alle LPL Receptor Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Reinheit & Dokumentation

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Calculators

Help & FAQs

XAX-162 Related Classifications

HY-182618 Related Classifications