UCHL1 - ubiquitin C-terminal hydrolase L1 Gene

Also Known as NDGOA; PARK5; PGP95; SPG79; PGP9.5; UCHL-1; Uch-L1; HEL-117; PGP 9.5; HEL-S-53

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 7345

About UCHL1

Cytogenetic location: 4p13 Genomic coordinates (GRCh38): 4:41,256,928-41,268,455 (from NCBI)

This gene has 12 transcripts (splice variants), 237 orthologues, 3 paralogues and is associated with 4 phenotypes. Biased expression in brain (RPKM 389.7), adrenal (RPKM 70.8) and 2 other tissues.

Summary

The protein encoded by this gene belongs to the peptidase C12 family. This enzyme is a thiol protease that hydrolyzes a peptide bond at the C-terminal glycine of ubiquitin. This gene is specifically expressed in the neurons and in cells of the diffuse neuroendocrine system. Mutations in this gene may be associated with Parkinson disease.[provided by RefSeq, Sep 2009]

UCHL1 Products (1)

mRNA	Protein	Name
NM_004181.5	NP_004172.2	ubiquitin carboxyl-terminal hydrolase isozyme L1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables alpha-2A adrenergic receptor binding	IPI IPI: Inferred from physical interaction	19477270	GOA
enables cysteine-type deubiquitinase activity	IDA IDA: Inferred from direct assay	9521656	GOA
enables cysteine-type deubiquitinase activity	IMP IMP: Inferred from mutant phenotype	34244144	GOA
enables cysteine-type endopeptidase activity	IDA IDA: Inferred from direct assay	8639624	GOA
enables omega peptidase activity	IDA IDA: Inferred from direct assay	9521656	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	12082530	GOA
enables ubiquitin binding	IDA IDA: Inferred from direct assay	9521656	GOA
enables ubiquitin protein ligase binding	IPI IPI: Inferred from physical interaction	19725078	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in negative regulation of MAP kinase activity	IDA IDA: Inferred from direct assay	19477270	GOA
involved in positive regulation of glycolytic process	IMP IMP: Inferred from mutant phenotype	34244144	GOA
involved in protein deubiquitination	IDA IDA: Inferred from direct assay	9521656	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	19477270	GOA
colocalizes with plasma membrane	IDA IDA: Inferred from direct assay	19477270	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

UCHL1 Protein Structure

Peptidase_C12

0
100
200
223 a.a.

Protein Preferred Names	Protein Names
ubiquitin carboxyl-terminal hydrolase isozyme L1	epididymis luminal protein 117

UCHL1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	UCHL1	P09936	UBE2I	Homo sapiens	Q7KZS0	Y2H Array	32814053
Intra	UCHL1	P09936	UBE2I	Homo sapiens	Q7KZS0	Validated Y2H	32814053
Intra	UCHL1	P09936	UBE2I	Homo sapiens	Q7KZS0	Y2H Pooling	32814053
Intra	UCHL1	P09936	CDK5	Homo sapiens	Q00535	Anti Tag CoIP	23543736
Intra	UCHL1	P09936	EIF1B	Homo sapiens	O60739	Validated Y2H	32814053
Intra	UCHL1	P09936	EIF1B	Homo sapiens	O60739	Y2H Array	32814053
Intra	UCHL1	P09936	EIF1B	Homo sapiens	O60739	Y2H Pooling	32814053
Intra	UCHL1	P09936	ATG5	Homo sapiens	Q9H1Y0	Validated Y2H	32814053
Intra	UCHL1	P09936	ATG5	Homo sapiens	Q9H1Y0	Y2H Array	32814053
Intra	UCHL1	P09936	ATG5	Homo sapiens	Q9H1Y0	Y2H Pooling	32814053
Intra	UCHL1	P09936	AP2B1	Homo sapiens	P63010-2	Y2H Array	32814053
Intra	UCHL1	P09936	AP2B1	Homo sapiens	P63010-2	Y2H Pooling	32814053
Intra	UCHL1	P09936	AP2B1	Homo sapiens	P63010-2	Validated Y2H	32814053
Intra	UCHL1	P09936	APP	Homo sapiens	P05067-2	Validated Y2H	32814053
Intra	UCHL1	P09936	APP	Homo sapiens	P05067-2	Y2H Array	32814053
Intra	UCHL1	P09936	APP	Homo sapiens	P05067-2	Y2H Pooling	32814053
Intra	UCHL1	P09936	NVL	Homo sapiens	O15381-5	Y2H Array	32814053
Intra	UCHL1	P09936	NVL	Homo sapiens	O15381-5	Y2H Pooling	32814053
Intra	UCHL1	P09936	NVL	Homo sapiens	O15381-5	Validated Y2H	32814053
Intra	UCHL1	P09936	MKL1	Homo sapiens	A4FUJ8	Validated Y2H	32814053
Intra	UCHL1	P09936	MKL1	Homo sapiens	A4FUJ8	Y2H Array	32814053
Intra	UCHL1	P09936	MKL1	Homo sapiens	A4FUJ8	Y2H Pooling	32814053
Intra	UCHL1	P09936	LAMP2	Homo sapiens	P13473-2	Validated Y2H	32814053
Intra	UCHL1	P09936	LAMP2	Homo sapiens	P13473-2	Y2H Pooling	32814053
Intra	UCHL1	P09936	LAMP2	Homo sapiens	P13473-2	Y2H Array	32814053
Intra	UCHL1	P09936	PCDHGC3	Homo sapiens	Q9BR81	Y2H Pooling	32814053
Intra	UCHL1	P09936	PCDHGC3	Homo sapiens	Q9BR81	Validated Y2H	32814053
Intra	UCHL1	P09936	PCDHGC3	Homo sapiens	Q9BR81	Y2H Array	32814053
Intra	UCHL1	P09936	TERF2	Homo sapiens	Q15554-4	Validated Y2H	32814053
Intra	UCHL1	P09936	TERF2	Homo sapiens	Q15554-4	Y2H Array	32814053
Intra	UCHL1	P09936	TERF2	Homo sapiens	Q15554-4	Y2H Pooling	32814053
Intra	UCHL1	P09936	ZC3HC1	Homo sapiens	Q86WB0-2	Validated Y2H	32814053
Intra	UCHL1	P09936	ZC3HC1	Homo sapiens	Q86WB0-2	Y2H Pooling	32814053
Intra	UCHL1	P09936	ZC3HC1	Homo sapiens	Q86WB0-2	Y2H Array	32814053
Intra	UCHL1	P09936	BRK1	Homo sapiens	Q8WUW1	Validated Y2H	32814053
Intra	UCHL1	P09936	BRK1	Homo sapiens	Q8WUW1	Y2H Array	32814053
Intra	UCHL1	P09936	BRK1	Homo sapiens	Q8WUW1	Y2H Pooling	32814053
Intra	UCHL1	P09936	CDK4	Homo sapiens	P11802	Pull Down	23543736
Intra	UCHL1	P09936	CDK4	Homo sapiens	P11802	Anti Tag CoIP	23543736
Intra	UCHL1	P09936	EGFR	Homo sapiens	P00533	Ub Reconstruction	20029029
Intra	UCHL1	P09936	IKBKE	Homo sapiens	Q14164	Y2H Array	32814053
Intra	UCHL1	P09936	IKBKE	Homo sapiens	Q14164	Y2H Pooling	32814053
Intra	UCHL1	P09936	IKBKE	Homo sapiens	Q14164	Validated Y2H	32814053
Intra	UCHL1	P09936	LSM8	Homo sapiens	O95777	Validated Y2H	32814053
Intra	UCHL1	P09936	LSM8	Homo sapiens	O95777	Y2H Array	32814053
Intra	UCHL1	P09936	LSM8	Homo sapiens	O95777	Y2H Pooling	32814053
Intra	UCHL1	P09936	USP21	Homo sapiens	Q9UK80	Validated Y2H	32814053
Intra	UCHL1	P09936	USP21	Homo sapiens	Q9UK80	Y2H Array	32814053
Intra	UCHL1	P09936	USP21	Homo sapiens	Q9UK80	Y2H Pooling	32814053
Intra	UCHL1	P09936	UBE2K	Homo sapiens	P61086	Y2H Array	32814053
Intra	UCHL1	P09936	UBE2K	Homo sapiens	P61086	Validated Y2H	32814053
Intra	UCHL1	P09936	UBE2K	Homo sapiens	P61086	Y2H Pooling	32814053
Intra	UCHL1	P09936	BIRC5	Homo sapiens	O15392	Validated Y2H	32814053
Intra	UCHL1	P09936	BIRC5	Homo sapiens	O15392	Y2H Pooling	32814053
Intra	UCHL1	P09936	BIRC5	Homo sapiens	O15392	Y2H Array	32814053
Intra	UCHL1	P09936	EVL	Homo sapiens	Q9UI08-2	Validated Y2H	32814053
Intra	UCHL1	P09936	EVL	Homo sapiens	Q9UI08-2	Y2H Array	32814053
Intra	UCHL1	P09936	EVL	Homo sapiens	Q9UI08-2	Y2H Pooling	32814053
Intra	UCHL1	P09936	ATF3	Homo sapiens	P18847	Y2H Array	32814053
Intra	UCHL1	P09936	ATF3	Homo sapiens	P18847	Validated Y2H	32814053
Intra	UCHL1	P09936	ATF3	Homo sapiens	P18847	Y2H Pooling	32814053
Intra	UCHL1	P09936	NEDD8	Homo sapiens	Q15843	Y2H Array	32814053
Intra	UCHL1	P09936	NEDD8	Homo sapiens	Q15843	Y2H Pooling	32814053
Intra	UCHL1	P09936	NEDD8	Homo sapiens	Q15843	Validated Y2H	32814053
Intra	UCHL1	P09936	RHEBL1	Homo sapiens	Q8TAI7	Validated Y2H	32814053
Intra	UCHL1	P09936	RHEBL1	Homo sapiens	Q8TAI7	Y2H Array	32814053
Intra	UCHL1	P09936	RHEBL1	Homo sapiens	Q8TAI7	Y2H Pooling	32814053
Intra	UCHL1	P09936	TERF2IP	Homo sapiens	Q9NYB0	Pull Down	21044950
Intra	UCHL1	P09936	APP	Homo sapiens	P05067	Lumier	32814053
Intra	UCHL1	P09936	CBX1	Homo sapiens	P83916	Y2H Pooling	32814053
Intra	UCHL1	P09936	CBX1	Homo sapiens	P83916	Validated Y2H	32814053
Intra	UCHL1	P09936	CBX1	Homo sapiens	P83916	Y2H Array	32814053

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant UCHL1 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P71096	UCHL1 Protein, Human (His, solution)	P09936 (M1-A223)	≥ 95%, as determined by reducing SDS-PAGE.

UCHL1 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P80785	PGP9.5 Antibody (YA231)	WB, IHC-P, IHC-F, ICC/IF, IP	Human, Mouse, Rat
HY-P80785A	PGP9.5 Antibody (YA231)(PBS only)	WB, IHC-P, IHC-F, ICC/IF, IP	Human, Mouse, Rat
HY-P84038	PGP9.5 Antibody (YA3735)	WB, IHC-P, ICC/IF, FC, ELISA	Human, Mouse, Rat
HY-P84038A	PGP9.5 Antibody (YA3735)(PBS only)	WB, IHC-P, ICC/IF, FC, ELISA	Human, Mouse, Rat
HY-P85926	PGP9.5 Antibody (YA5618)	IHC-P, WB, ICC/IF, ELISA	Human, Mouse, Rat
HY-P86000	PGP9.5 Antibody (YA5692)	IHC-P, ELISA, ICC/IF,	Human, Mouse, Rat
HY-P86573	PGP9.5 Antibody (YA6265)	WB, IHC-P, ICC/IF, IP, ELISA	Human, Mouse, Rat
HY-P86680	PGP9.5 Antibody (YA6372)	WB, IHC-P, IHC-F, IF-Tissue	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Spastic Paraplegia 79, Autosomal Recessive	Early-Onset Progressive Neurodegeneration-Blindness-Ataxia-Spasticity Syndrome SPG79 Neurodegeneration With Optic Atrophy, Childhood-Onset Ndgoa Hereditary Spastic Paraplegia 79 Spastic Paraplegia 79 Autosomal Recessive Doid:0112344 Neurodegeneration, With Optic Atrophy, Childhood-Onset
Parkinson Disease 5, Autosomal Dominant	Parkinson Disease 5, Autosomal Dominant, Susceptibility To Parkinson Disease 5 PARK5 Parkinson Disease 5, Susceptibility To Parkinson Disease Autosomal Dominant 5 Parkinson Disease, Type 5
Parkinson Disease 2, Autosomal Recessive Juvenile	Young-Onset Parkinson Disease PARK2 Pdj Autosomal Recessive Juvenile Parkinson Disease 2 Epdf Parkinson Disease, Juvenile, Type 2 Parkinson'S Disease 2 Autosomal Recessive Juvenile Parkinson Disease Early-Onset Parkinson Disease Parkinson Disease 2 Parkinson Disease, Juvenile, Autosomal Recessive Parkinsonism, Early-Onset, With Diurnal Fluctuation Autosomal Recessive Juvenile Parkinson'S Disease 2 Jp Juvenile Parkinsonism Parkinson Disease Autosomal Recessive, Early Onset Parkinsonism, Early Onset, With Diurnal Fluctuation Yopd Autosomal Recessive Early-Onset Parkinson Disease Type 2 Chromosome 6-Linked Autosomal Recessive Parkinsonism Early-Onset Parkinsonism With Diurnal Fluctuation Parkinsonism Young Adult Onset Parkinson Disease, Type 2 Parkinsonism, Juvenile
Hodgkin'S Paragranuloma	Hodgkin Paragranuloma Hodgkin Disease
Parathyroid Carcinoma	Parathyroid Cancer Parathyroid Neoplasms Malignant Tumor Of Parathyroid Gland PRTC Carcinoma Of Parathyroid Gland Malignant Neoplasm Of Parathyroid Gland Parathyroid Gland Adenocarcinoma Parathyroid Gland Cancer Parathyroid Neoplasm Parathyroid Gland Carcinoma Malignant Neoplasm Of The Parathyroid Neoplasm Of Parathyroid Gland Parathyroid Gland Neoplasm Cancer Of The Parathyroid Cancer Of The Parathyroid Gland Malignant Neoplasm Of Parathyroid Malignant Parathyroid Gland Neoplasm Malignant Parathyroid Gland Tumor Malignant Parathyroid Neoplasm Malignant Parathyroid Tumor Malignant Tumor Of Parathyroid Parathyroid Adenocarcinoma Neoplasm Of The Parathyroid Gland Carcinoma, Parathyroid
Granular Cell Tumor	Abrikosov'S Tumor Neoplasm Of Granular Cell Abrikosoff'S Granulous Cell Tumor Abrikosoff'S Tumor Giant Granulocellular Abrikosov'S Tumor Malignant Variant Of Abrikosov'S Tumor Carcinoma, Granular Cell
Parkinsonism	Parkinsonism-Plus Idiopathic Parkinsonism Primary Parkinsonism Paralysis Agitans Syndrome Parkinsonian Syndrome Trembling Paralysis Paralysis Agitans Shaking Palsy Shaking Paralysis
Parkinson Disease, Late-Onset	Parkinson Disease Parkinson'S Disease PD PARK Parkinson Disease, Susceptibility To Late Onset Parkinson'S Disease Late Onset Parkinson Disease Paralysis Agitans Primary Parkinsonism Idiopathic Parkinson Disease Parkinson'S Parkinson Disease, Late-Onset, Susceptibility To Parkinson Disease, Age Of Onset, Modifier Lewy Body Parkinson Disease Idiopathic Parkinson'S Disease Pd - [Parkinson Disease] Parkinson Disease Nos Parkinson, Nos Primary Parkinson Disease
Dementia	Dementias Presenile Dementia Alzheimer Type Dementia Alzheimer Sclerosis Alzheimer Disease Dementia Alzheimer Dementia Primary Degenerative Alzheimer Type Dementia End Stage Alzheimer'S Dementia Alzheimer'S Type Atypical Dementia Alzheimer Type Presenile Dementia Early Onset Alzheimer Dementia Dementia In Alzheimer Disease Type 2 Dementia In Alzheimer Disease With Early Onset Early Onset Alzheimer Type Dementia, Uncomplicated Primary Degenerative Alzheimer Type Dementia, Early Onset Primary Degenerative Alzheimer Type Dementia, Presenile Onset, Uncomplicated Alzheimer Disease Dementia With Early Onset Presenile Sclerosis Presenile Brain Sclerosis Presenile Alzheimer Brain Sclerosis Late Onset Alzheimer Dementia Dementia In Alzheimer Disease Type 1 Dementia In Alzheimer Disease With Late Onset Primary Degenerative Alzheimer Type Dementia, Late Onset Sdat - [Senile Dementia, Alzheimer Type] Alzheimer Disease Dementia With Late Onset Late Onset Alzheimer Brain Sclerosis Senile Alzheimer Brain Disease Senile Alzheimer Brain Sclerosis Senile Primary Degenerative Alzheimer Type Dementia Senile Dementia Of The Alzheimer Type Arteriosclerotic Dementia Strategic-Infarct Dementia Post Stroke Dementia Vascular Cognitive Impairment Vascular Dementia Dementia Of The Lewy Body Type Dementia With Lewy Bodies Sdlt - [Senile Dementia Of The Lewy Body Type] Senile Dementia Of The Lewy Body Type Alcohol-Related Dementia Alcoholic Dementia Nos Alcohol-Induced Dementia Alcoholic Brain Syndrome Chronic Alcoholic Brain Syndrome Alcohol Dementia Late Onset Alcoholic Psychosis Residual And Late-Onset Alcohol-Induced Psychotic Disorder Mental And Behavioural Disorders Due To Use Of Sedatives Or Hypnotics, Residual And Late-Onset Psychotic Disorder Late-Onset Psychoactive Substance-Induced Psychotic Disorder Inhalant Dementia Volatile Solvents Dementia Dementia In Paralysis Agitans Pdd - [Parkinson Disease Dementia] Dementia Syndrome Of Parkinson Disease Dementia In Parkinson Disease Parkinson Related Dementia Dementia In Huntington Chorea Hiv - [Human Immunodeficiency Virus] Dementia Hiv- [Human Immunodeficiency Virus] Associated Cognitive Motor Complex Hiv- [Human Immunodeficiency Virus] Associated Dementia Complex Aids - [Acquired Immunodeficiency Syndrome] Dementia Complex Aids Related Dementia Dementia Due To Niacin Deficiency
Cauda Equina Neoplasm	Tumor Of The Cauda Equina Neoplasm Of Cauda Equina
Spasticity
Hodgkin'S Lymphoma, Mixed Cellularity	Hodgkin'S Disease, Mixed Cellularity Hodgkins Lymphoma, Mixed Cellularity Mixed Cellularity Hodgkin Lymphoma
Cardiac Arrest	Cardiopulmonary Arrest Circulatory Arrest Heart Arrest
Acquired Gastric Outlet Stenosis	Adult Hypertrophic Pyloric Stenosis Acquired Hypertrophic Pyloric Stenosis
Large Cell Carcinoma	Carcinoma, Large Cell Carcinoma Large Cell
Hypertrophic Pyloric Stenosis	Congenital Hypertrophic Pyloric Stenosis Pyloric Stenosis, Hypertrophic Congenital Or Infantile Stricture Of Pylorus Achalasia Of The Pylorus Congenital Hypertrophy Of The Pylorus Infantile Hypertrophy Of The Pylorus Infantile Constriction Of The Pylorus Congenital Stenosis Of The Pylorus Congenital Constriction Of The Pylorus Congenital Stricture Of The Pylorus Infantile Hypertrophic Pyloric Stenosis Infantile Stenosis Of The Pylorus Infantile Stricture Of The Pylorus Congenital Or Infantile Constriction Of Pylorus Infantile Pyloric Obstruction Infantile Pyloric Hypertrophy Pylorus Achalasia Pyloric Constriction Infantile Pyloric Stricture Infantile Pyloric Stenosis Congenital Spasm Of Pylorus Congenital Pylorospasm Congenital Pyloric Stricture Congenital Pyloric Spasm Congenital Or Infantile Spasm Of Pylorus Congenital Or Infantile Obstruction Of Pylorus Congenital Pyloric Stenosis
Parkinson Disease 3, Autosomal Dominant	PARK3 Parkinson Disease 3 Parkinson Disease 3, Autosomal Dominant Lewy Body Parkinson'S Disease 3 Autosomal Dominant Lewy Body Parkinson Disease 3 Autosomal Dominant Parkinson Disease 3 Parkinson Disease Type 3 Autosomal Dominant Parkinson Disease Parkinson Disease, Autosomal Dominant Parkinson Disease, Familial, Type 1
Motor Neuron Disease	Anterior Horn Cell Disease Motor Neuron Diseases Mnd - [Motor Neurone Disease] Lou Gehrig Disease Creeping Palsy Creeping Paralysis Bulbar Motor Neuron Disease Bulbar Syndrome Anterior Horn Cell Disorder Hereditary Motor Neuron Disease
Lung Cancer	Lung Carcinoma Non-Small Cell Lung Carcinoma Lung Cancer, Susceptibility To Lung Cancer, Protection Against Adenocarcinoma Of Lung, Somatic Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In Nonsmall Cell Lung Cancer Lung Neoplasm Carcinoma Of Lung Lung Non-Small Cell Carcinoma Non-Small Cell Lung Cancer Nsclc Lung Neoplasms Malignant Neoplasm Of Lung Alveolar Cell Carcinoma Nonsmall Cell Lung Cancer, Somatic Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In Nonsmall Cell Lung Cancer, Susceptibility To Lung Cancer, Somatic Lung Cancer, Resistance To Cancer Of Lung Cancer Of Bronchus Cancer Of The Lung Lung Malignancies Lung Malignant Tumors Malignant Lung Tumor Malignant Tumor Of Lung Pulmonary Cancer Pulmonary Carcinoma Pulmonary Neoplasms Respiratory Carcinoma LNCR Adenocarcinoma Of Lung Neoplasm Of Lung Cancer Lung Carcinoma Non-Small Cell Lung Carcinoma, Non-Small-Cell Lung Lung Cancers Lung Carcinomas Cancer, Lung Cancer, Lung, Non-Small Cell Primary Malignant Neoplasm Of Lung Bronchioloalveolar Adenocarcinoma
Diabetic Polyneuropathy	Diabetes Mellitus With Polyneuropathy Polyneuropathy In Diabetes Diabetic Polyneuropathies Diabetic Neuropathy Nos
Sensory Peripheral Neuropathy	Sensory Neuropathy Peripheral Sensory Neuropathy Hereditary Sensory And Autonomic Neuropathies
Thyroid Gland Hurthle Cell Carcinoma	Oncocytic Carcinoma Of The Thyroid Thyroid Cancer, Hurthle Cell
Hepatocellular Carcinoma	Liver Cancer Primary Liver Cancer HCC Hepatoma Malignant Neoplasm Of Liver Liver Neoplasms Cancer, Hepatocellular Liver Cell Carcinoma Lcc Hepatoblastoma, Somatic Hepatic Cancer Primary Malignant Neoplasm Of Liver Rare Tumor Of Liver And Intrahepatic Biliary Tract Hepatocellular Carcinoma, Somatic Hepatocellular Carcinoma, Childhood Type, Somatic Hepatocellular Cancer, Somatic Ca Liver - Primary Hepatic Neoplasm Malignant Hepato-Biliary Neoplasm Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary Malignant Neoplasm Of Liver, Primary Malignant Tumor Of Liver Neoplasm Of Liver Non-Resectable Primary Hepatic Malignant Neoplasm Resectable Malignant Neoplasm Of Liver Resectable Malignant Neoplasm Of The Liver Primary Liver Carcinoma Primary Malignant Liver Neoplasm Primary Cancer Of Liver Primary Tumor Of The Liver Rare Tumor Of Liver And Ibt Hepatocellular Cancer Neoplasm Of The Liver Carcinoma, Hepatocellular Hepatomas Liver Neoplasm Liver Carcinoma Liver And Intrahepatic Biliary Tract Carcinoma Malignant Hepatobiliary Neoplasm Adult Primary Hepatocellular Carcinoma Hepatoblastoma Carcinoma Of Liver Malignant Liver Tumour Malignant Hepatic Tumour
Diabetic Neuropathy	Diabetic Neuropathies
Megacolon	Dilatation Of Colon
Alzheimer Disease, Familial, 1	Alzheimer Disease Alzheimer'S Disease Presenile And Senile Dementia AD1 Alzheimer Disease, Susceptibility To Alzheimer Disease, Late-Onset, Susceptibility To Alzheimer Disease 1, Familial AD Familial Alzheimer Disease Alzheimer Disease, Late-Onset Alzheimers Dementia Alzheimer Dementia Alzheimer Sclerosis Alzheimer Syndrome Alzheimer-Type Dementia Dat Primary Senile Degenerative Dementia Sdat Alzheimer Disease 1 Autosomal Dominant Alzheimer Disease Early-Onset Alzheimer Disease With Cerebral Amyloid Angiopathy Late Onset Alzheimer Disease Alzheimers Disease Alzheimer Disease, Early-Onset, With Cerebral Amyloid Angiopathy Late-Onset Alzheimers Disease Alzheimer'S Disease Pathway Kegg Dementia Due To Alzheimer'S Disease Alzheimer Disease Type 1 Alzheimers
Colorectal Cancer	Colon Cancer Colorectal Carcinoma Colon Carcinoma Colorectal Cancer, Susceptibility To Carcinoma Of Colon CRC Colorectal Cancer With Chromosomal Instability, Somatic Colon Cancer, Somatic Colon Cancer, Susceptibility To Colonic Neoplasms Colorectal Neoplasms Colorectal Cancer, Somatic Colon Cancer, Advanced, Somatic Colonic Carcinoma Colorectal Carcinomas Colon Cancers Colorectal Cancers Cancer, Colorectal, Somatic Cancer, Colon Cancer, Colorectal, Susceptibility To Colorectal Neoplasm Colonic Neoplasm Malignant Tumor Of Colon
Huntington Disease	Huntington'S Disease Huntington Chorea Huntington'S Chorea HD Huntington Chronic Progressive Hereditary Chorea Juvenile Huntington Disease Chronic Progressive Chorea Chronic Progressive Hereditary Chorea Hc - [Huntington Chorea] Hereditary Chorea Progressive Hereditary Chorea
Dementia, Lewy Body	Lewy Body Dementia Lewy Body Disease Diffuse Lewy Body Disease Dementia With Lewy Bodies DLB Autosomal Dominant Diffuse Lewy Body Disease Cortical Lewy Body Disease Dementia, Lewy Body, Susceptibility To Lewy Body Dementia, Susceptibility To Senile Dementia Of The Lewy Body Type Dementia Of The Lewy Body Type Lbd Diffuse Lewy Body Disease With Gaze Palsy Dysphasic Dementia Hereditary Lewy Body Type Senile Dementia Lewy Body Variant Of Alzheimer Disease Lewy Bodies Lewy Body Dlbd - [Diffuse Lewy Body Disease] Clbd - [Cortical Lewy Body Disease]
Hirschsprung Disease 1	Hirschsprung Disease Aganglionic Megacolon Hscr Hirschsprung'S Disease Congenital Megacolon Congenital Intestinal Aganglionosis Colonic Aganglionosis Hirschsprung Disease, Susceptibility To, 1 Hirschsprung Disease, Protection Against HSCR1 Mgc Pelvirectal Achalasia Total Intestinal Aganglionosis Megacolon, Aganglionic Macrocolon Hscr 1 Hirschsprung Disease Type 1 Hirschsprung Disease, Type 1 Congenital Dilatation Of Colon Aganglionosis Congenital Aganglionic Megacolon Aganglionosis Of Colon Bowel Aganglionosis Colon Aganglionosis Hirschsprung Megacolon
Movement Disease	Movement Disorders Movement Disorder
Peripheral Nervous System Disease	Peripheral Neuropathy Peripheral Nerve Disease Peripheral Nerve Disorders Neuropathy, Peripheral Peripheral Neuropathy Due To Vitamin Pyridoxine Hyperalimentation
Intracranial Berry Aneurysm	Familial Aneurysmal Subarachnoid Hemorrhage Familial Berry Aneurysm Familial Intracranial Saccular Aneurysm Saccular Cerebral Aneurysm Aneurysm, Intracranial Berry Aneurysmal Subarachnoid Hemorrhage Aneurysm, Intracranial Berry, 1
Autosomal Dominant Cerebellar Ataxia	Spinocerebellar Ataxia Adca Pierre Marie Cerebellar Ataxia Ataxia, Spinocerebellar Sca Autosomal Dominant Spinocerebellar Ataxia Spinocerebellar Ataxias
Nervous System Disease	Abnormality Of The Nervous System Nervous System Diseases Nervous System Disorder
Amyotrophic Lateral Sclerosis 1	Amyotrophic Lateral Sclerosis ALS Lou Gehrig Disease Amyotrophic Lateral Sclerosis Type 1 Charcot Disease ALS1 Amyotrophic Lateral Sclerosis, Susceptibility To Fals Lou Gehrig'S Disease Mnd Motor Neuron Disease Familial Amyotrophic Lateral Sclerosis Amyotrophic Lateral Sclerosis 1, Familial Amyotrophic Lateral Sclerosis 1, Autosomal Dominant Motor Neuron Disease, Bulbar Motor Neurone Disease Amyotrophic Lateral Sclerosis With Dementia Dementia With Amyotrophic Lateral Sclerosis Motor Neuron Disease, Amyotrophic Lateral Sclerosis Sclerosis, Lateral, Amyotrophic Sclerosis, Lateral, Amyotrophic, Type 1 Amyotrophic Sclerosis Als - [Amyotrophic Lateral Sclerosis] Wasting Palsy Amyotrophic Paralysis Amyotrophy Lateral Sclerosis Wasting Paralysis Spinal Progressive Amyotrophy Progressive Atrophic Paralysis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-153627	GK13S	Inhibitor	99.09%	Unkown
HY-161378	UCHL1-IN-1	Inhibitor	98.0%	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	UCHL1	MGD	MGI:103149
Rattus norvegicus	UCHL1	RGD	RGD:3928
Canis familiaris	UCHL1	VGNC	VGNC:58342
Felis catus	UCHL1	VGNC	VGNC:66795
Macaca mulatta	UCHL1	VGNC	VGNC:78705
Bos taurus	UCHL1	VGNC	VGNC:36631
Others	UCHL1	NCBI