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Cat. No.: HY-148275

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KTX-955

KTX-955 is an antumor and effective IRAK4 degrader, with DC₅₀ values of 5 nM and 130 nM for IRAK4 and Ikaros, respectively.
(Pink: IRAK4 ligand (HY-150735); Blue: Cereblon ligand (HY-10984); Black: linker).

For research use only. We do not sell to patients.

CAS No.: 2573302-50-6
Formula: C₄₆H₅₁F₃N₈O₇
Molecular Weight:884.94

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (265 KB)

KTX-955 Chemical Structure

CAS No.: 2573302-50-6

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- Cellular Effect
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

KTX-955 is an antumor and effective IRAK4 degrader, with DC₅₀ values of 5 nM and 130 nM for IRAK4 and Ikaros, respectively^[1]. (Pink: IRAK4 ligand (HY-150735); Blue: Cereblon ligand (HY-10984); Black: linker).

IC₅₀ & Target^[1]

IRAK4

5 nM (IC₅₀)

All PROTACs Isoforms :

All IRAK Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
OCI-Ly10	IC₅₀	2300 nM Compound: 20	Antiproliferative activity against human OCI-Ly10 cells measured after 4 days by CellTiter-Glo Luminescent Cell Viability Assay Antiproliferative activity against human OCI-Ly10 cells measured after 4 days by CellTiter-Glo Luminescent Cell Viability Assay	[PMID: 38920289]

In Vitro

KTX-955 (compound I-312) degrades IRAK4 in OCI-LY10 at 24 hours with an IC₅₀ of <0.05 μM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 2573302-50-6
Molecular Weight 884.94
Formula C₄₆H₅₁F₃N₈O₇
SMILES

O=C(N1C2C(NC(CC2)=O)=O)C3=CC=CC(N[C@H]4C[C@@H](C4)OC5CCN(CC5)C[C@H]6CC[C@H](N7C=C8C(C=C(C(NC(C9=CC=CC(C(F)(F)F)=N9)=O)=C8)C(C)(O)C)=N7)CC6)=C3C1=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (265 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Matthew Weiss. Discovery and characterization of IRAKIMiDs: degraders targeting both IRAK4 and IMiD substrates for oncology indications. Northeastern Section, ACS (NESACS).

[2]. Nello Mainolfi, et al. Irak degraders and uses thereof. WO2020264499A1

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

MOQ

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100 mg

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Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References

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KTX-955

All PROTACs Isoforms

All IRAK Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

KTX-955 Related Classifications

HY-148275 Related Classifications