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Cat. No.: HY-186303

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Onzotrigine

Name: Onzotrigine
Brand: MedChemExpress
SKU: HY-186303
Availability: PreOrder

(Synonyms: LTG-001)

Onzotrigine (LTG-001) is a potent, selective, voltage-gated sodium channel Nav1.8 inhibitor. Onzotrigine may be used in pain-related research.

For research use only. We do not sell to patients.

CAS No.: 2834099-10-2
Formula: C₂₁H₁₈F₄N₄O₃S
Molecular Weight:482.45

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Onzotrigine Chemical Structure

CAS No.: 2834099-10-2

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vivo
Chemical Information
Purity & Documentation
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Biological Activity

Description

Onzotrigine (LTG-001) is a potent, selective, voltage-gated sodium channel Nav1.8 inhibitor. Onzotrigine may be used in pain-related research^[1].

IC₅₀ & Target^[1]

Nav1.8

All Sodium Channel Isoforms :

In Vivo

Onzotrigine (LTG-001) (low dose: 300 mg loading dose, followed by 150 mg every 12 hours; high dose: 450 mg loading dose, followed by 300 mg every 12 hours; 48 hours) showed superior analgesia to placebo for moderate to severe postoperative pain after abdominoplasty, as evidenced by higher SPID48 values^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 2834099-10-2
Molecular Weight 482.45
Formula C₂₁H₁₈F₄N₄O₃S
SMILES

C[S@@](C1=CC=CC(NC(C2=C(N=CC(C(F)(F)F)=C2C)OC3=C(N=C(C=C3)F)C)=O)=C1)(=N)=O
Synonyms

LTG-001
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Singla N, et al. Phase 2b Trial of a NaV1.8 Inhibitor for Acute Pain. N Engl J Med. 2026 Jul 30;395(5):454-464.

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Biological Activity
- Description
- IC₅₀ & Target
- In Vivo
Chemical Information
Purity & Documentation
References

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Onzotrigine

All Sodium Channel Isoforms