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Cat. No.: HY-157148

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1D228

1D228 is a c-Met/TRK inhibitor with antitumor activity. 1D228 inhibits cyclin D1 to induce G0/G1 arrest and inhibit cancer cell proliferation and migration. 1D228 can be used in the study of gastric, liver and vascular tumors.

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CAS No.: 2925447-16-9
Formule: C₃₀H₂₉DN₆O₂
Masse moléculaire:507.60

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (264 KB)

1D228 Chemical Structure

CAS No.: 2925447-16-9

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- Cellular Effect
- Application
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
Bioz

Activité biologique

Description

Voir tous les produits spécifiques à Isoform Trk Receptor :

Cellular Effect

Cell Line	Type	Value	Description	References
MHCC97H	IC₅₀	4.3 nM Compound: 84; 1D228	Antiproliferative activity against human MHCC97H cells assessed as cell growth inhibition incubated for 48 hrs by MTT assay Antiproliferative activity against human MHCC97H cells assessed as cell growth inhibition incubated for 48 hrs by MTT assay	[PMID: 38733884]
MKN-45	IC₅₀	1 nM Compound: 84; 1D228	Antiproliferative activity against human MKN-45 cells assessed as cell growth inhibition incubated for 48 hrs by MTT assay Antiproliferative activity against human MKN-45 cells assessed as cell growth inhibition incubated for 48 hrs by MTT assay	[PMID: 38733884]

Application

1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.

Chemical Information

CAS No. 2925447-16-9
Masse moléculaire 507.60
Formule C₃₀H₂₉DN₆O₂
SMILES

[2H][C@@](C1=CC=CC(C2=NC=C(C=N2)OCC3CCN(CC3)C)=C1)(N4N=C(C=CC4=O)C5=CC=CC(C#N)=C5)C
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (264 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. An B, et al. A novel c-Met/TRK inhibitor 1D228 efficiently inhibits tumor growth by targeting angiogenesis and tumor cell proliferation. Cell Death Dis. 2023 Nov 9;14(11):728. [Content Brief]

Calculators

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculateur de dilution

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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