2-Methylacetophenone
Based on 1 Customer Validation
2-Methylacetophenone (O-Methylacetophenone), acetophenone derivative and acaricide, is a xanthine dehydrogenase (XDH) inhibitor. 2-Methylacetophenone competitively binds to the XDH active site, blocking the pathway for xanthine to be converted to uric acid. 2-Methylacetophenone can be used for the study of hyperuricemia and house dust.
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- Pureté: 99.39%
- CAS No.: 577-16-2
- Formule: C9H10O
- Masse moléculaire:134.18
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Stockage:Pure form -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Activité biologique
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Chemical Information
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Solvant et solubilité
- Pureté et documentation
- Références
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Activité biologique
2-Methylacetophenone (0.64-1.25 μg/cm2; 24 h) exhibits potent acaricidal activity against D. farinae, with an LD50 of 1.25 μg/cm2 in vapor phase assays (8.00 times more toxic than benzyl benzoate) and an LD50 of 0.64 μg/cm2 in contact phase assays (11.75 times more toxic than benzyl benzoate)[1].
2-Methylacetophenone (0.75-1.43 μg/cm2; 24 h) exhibits potent acaricidal activity against D. pteronyssinus, with an LD50 of 1.43 μg/cm2 in vapor phase assays (6.69 times more toxic than benzyl benzoate) and an LD50 of 0.75 μg/cm2 in contact phase assays (8.02 times more toxic than benzyl benzoate)[1].
2-Methylacetophenone (1.45-2.68 μg/cm2; 24 h) exhibits potent acaricidal activity against T. putrescentiae, with an LD50 of 2.68 μg/cm2 in vapor phase assays (4.56 times more toxic than benzyl benzoate) and an LD50 of 1.45 μg/cm2 in contact phase assays (7.31 times more toxic than benzyl benzoate)[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:adult mites[1]
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Dosage:1.25 μg/cm2; 0.64 μg/cm2
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Administration:24 h
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Result:Achieved an LD50 of 1.25 μg/cm2 against D. farinae in vapor phase toxicity bioassay, with a relative toxicity of 8.00 compared to benzyl benzoate.
Achieved an LD50 of 0.64 μg/cm2 against D. farinae in contact toxicity bioassay, with a relative toxicity of 11.75 compared to benzyl benzoate.
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Animal Model:adult mites[1]
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Dosage:1.43 μg/cm2; 0.75 μg/cm2
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Administration:24 h
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Result:Achieved an LD50 of 1.43 μg/cm2 against D. pteronyssinus in vapor phase toxicity bioassay, with a relative toxicity of 6.69 compared to benzyl benzoate.
Achieved an LD50 of 0.75 μg/cm2 against D. pteronyssinus in contact toxicity bioassay, with a relative toxicity of 8.02 compared to benzyl benzoate.
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Animal Model:adult mites[1]
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Dosage:2.68 μg/cm2; 1.45 μg/cm2
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Administration:24 h
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Result:Achieved an LD50 of 2.68 μg/cm2 against T. putrescentiae in vapor phase toxicity bioassay, with a relative toxicity of 4.56 compared to benzyl benzoate.
Achieved an LD50 of 1.45 μg/cm2 against T. putrescentiae in contact toxicity bioassay, with a relative toxicity of 7.31 compared to benzyl benzoate.
Chemical Information
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CAS No. 577-16-2
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Appearance Liquid (Density: 1.026 g/cm3)
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Masse moléculaire 134.18
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Formule C9H10O
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Color Colorless to light yellow
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SMILES
CC(C1=CC=CC=C1C)=O
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Synonyms
O-Methylacetophenone
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Structure Classification
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Initial Source
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Pure form -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvant et solubilité
DMSO : 100 mg/mL (745.27 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (18.63 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.5 mg/mL (18.63 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL.
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Pureté et documentation
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Fiche technique (276 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Instruction de manipulation (2659 KB)
Références
[1]. Oh MS, Yang JY, Lee HS. Acaricidal toxicity of 2'-hydroxy-4'-methylacetophenone isolated from Angelicae koreana roots and structure-activity relationships of its derivatives. J Agric Food Chem. 2012 Apr 11;60(14):3606-11. [Content Brief]
[2]. Chen M, et al. Potential candidates from a functional food Zanthoxyli Pericarpium (Sichuan pepper) for the management of hyperuricemia: high-through virtual screening, network pharmacology and dynamics simulations. Front Endocrinol (Lausanne). 2024 Dec 11;15:1436360. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 7.4527 mL | 37.2634 mL | 74.5268 mL | 186.3169 mL |
| 5 mM | 1.4905 mL | 7.4527 mL | 14.9054 mL | 37.2634 mL | |
| 10 mM | 0.7453 mL | 3.7263 mL | 7.4527 mL | 18.6317 mL | |
| 15 mM | 0.4968 mL | 2.4842 mL | 4.9685 mL | 12.4211 mL | |
| 20 mM | 0.3726 mL | 1.8632 mL | 3.7263 mL | 9.3158 mL | |
| 25 mM | 0.2981 mL | 1.4905 mL | 2.9811 mL | 7.4527 mL | |
| 30 mM | 0.2484 mL | 1.2421 mL | 2.4842 mL | 6.2106 mL | |
| 40 mM | 0.1863 mL | 0.9316 mL | 1.8632 mL | 4.6579 mL | |
| 50 mM | 0.1491 mL | 0.7453 mL | 1.4905 mL | 3.7263 mL | |
| 60 mM | 0.1242 mL | 0.6211 mL | 1.2421 mL | 3.1053 mL | |
| 80 mM | 0.0932 mL | 0.4658 mL | 0.9316 mL | 2.3290 mL | |
| 100 mM | 0.0745 mL | 0.3726 mL | 0.7453 mL | 1.8632 mL |
2-Methylacetophenone Related Classifications
HY-W012658 Related Classifications
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- 2-Methylacetophenone
- 577-16-2
- O-Methylacetophenone
- Xanthine Oxidase
- acetophenone derivative
- Dermatophagoides farinae
- stored food mite infestations
- house dust mite infestations
- contact exposure
- acaricide
- benzyl benzoate
- Tyrophagus putrescentiae
- Dermatophagoides pteronyssinus
- xanthine dehydrogenase
- uric acid
- Inhibitor
- inhibitor
- inhibit