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Cat. No.: HY-156562B

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5-PT TFA

(Synonyms: 5-Propargyltryptamide TFA)

1 Cited Publications

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5-PT (5-Propargyltryptamide) TFA is an alkyne-functionalized derivative of 5-HT (HY-B1473A) and serotonylation substrate that can be taken up by living cells. After conjugation with biotin, 5-PT TFA enables the identification of serotonylated proteins via copper click chemistry and mass spectrometry. 5-PT TFA can label and isolate serotonylated cells in alveolar epithelial cells for proteomic analysis. 5-PT TFA is applicable to research related to bronchopulmonary dysplasia.

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CAS No.: 3117303-22-4
Formule: C₁₅H₁₅F₃N₂O₃
Masse moléculaire:328.29

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5-PT TFA Chemical Structure

CAS No.: 3117303-22-4

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

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Bioz

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Description

In Vitro

5-PT (100 μM; 24 h) TFA labels 121 unique serotonylated proteins in MLE-12 alveolar epithelial cells, with many of these proteins linked to cellular processes and cell behavior regulation^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 3117303-22-4
Masse moléculaire 328.29
Formule C₁₅H₁₅F₃N₂O₃
SMILES

O=C(C(F)(F)F)O.C#CCOC1=CC2=C(NC=C2CCN)C=C1
Synonyms

5-Propargyltryptamide TFA
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

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iScience

5-HT promotes bronchopulmonary dysplasia via TGM2-mediated serotonylation. [Abstract]

2025 Nov 19;28(12):114120. PMID: 41438086

Pureté et documentation

Instruction de manipulation (2659 KB)

Références

[1]. Cai P, Ding R, Yin C, et al.. 5-HT promotes bronchopulmonary dysplasia via TGM2-mediated serotonylation. iScience. 2025 Dec 19;28(12):114120. [Content Brief]

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How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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5-PT TFA

1 Cited Publications

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5-PT TFA

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