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Cat. No.: HY-101602

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Aligeron

Aligeron is a non-selective prostaglandin (PG) antagonist, and has vasodilatory properties.

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CAS No.: 70713-45-0
Formule: C₂₀H₂₄N₂
Masse moléculaire:292.42

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Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (267 KB)

Aligeron Chemical Structure

CAS No.: 70713-45-0

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Activité biologique
- Description
- In Vitro
- In Vivo
Chemical Information
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Activité biologique

Description

Aligeron is a non-selective prostaglandin (PG) antagonist, and has vasodilatory properties.

Voir tous les produits spécifiques à Isoform Prostaglandin Receptor :

In Vitro

Aligeron shows a broad spectrum of antagonistic action against different spasmogens in different isolated organs. The experiments on isolated perfused rabbit artery shows the antagonistic action of aligeron against the vasoconstrictor effects of noradrenaline and adrenaline^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

In hypoventilation hypoxia, aligeron (5 mg/kg i.v.) and cinnarizine increase cortical resistance to hypoxia and accelerated the recovery of cortical bioelectrical activity. In KCl- and AMP-induced depressions aligeron shows a protective effect manifested in a decrease of the degree and duration of the depression^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 70713-45-0
Masse moléculaire 292.42
Formule C₂₀H₂₄N₂
SMILES

C=CCN1CCN(C(C2=CC=CC=C2)C3=CC=CC=C3)CC1
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (267 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Miyares K, et al. Antagonistic activity of aligeron and papaverine against different smooth muscle stimuli. Methods Find Exp Clin Pharmacol. 1985 Sep;7(9):473-6. [Content Brief]

[2]. Dimov S, et al. Effect of aligeron and cinnarizine in models of general and local depression of the cortical bioelectrical activity in cats. Methods Find Exp Clin Pharmacol. 1983;5(2):89-95. [Content Brief]

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How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Références

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Aligeron

Voir tous les produits spécifiques à Isoform Prostaglandin Receptor

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Aligeron Related Classifications

HY-101602 Related Classifications