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Obeticholic acid

(Synonyms: INT-747; 6-ECDCA; 6-Ethylchenodeoxycholic acid)
86 Cited Publications
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Based on 86 publication(s) in Google Scholar

Obeticholic acid (INT-747) is a potent, selective and orally active FXR agonist with an EC50 of 99 nM. Obeticholic acid has anticholeretic and anti-inflammation effect. Obeticholic acid also induces autophagy.

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  • Pureté: 99.94%
  • CAS No.: 459789-99-2
  • Formule: C26H44O4
  • Masse moléculaire:420.63
  • Stockage:
    Powder   -20°C, 3 years , 4°C, 2 years ; In solvent   -80°C, 6 months , -20°C, 1 month
  • Obeticholic acid Chemical Structure
    Obeticholic acid Chemical Structure
  • Experimental Validation Results for Obeticholic acid
  • Experimental Validation Results for Obeticholic acid
  • Experimental Validation Results for Obeticholic acid
  • Experimental Validation Results for Obeticholic acid
  • Experimental Validation Results for Obeticholic acid
  • Experimental Validation Results for Obeticholic acid
CAS No.: 459789-99-2
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  • Obeticholic acid Chemical Structure
    Obeticholic acid Chemical Structure
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    Obeticholic acid purchased from MedChemExpress. Usage Cited in: Bone Res. 2025 Jan 30;13(1):20. [Abstract]

    Customer Validation
     Representative images of hematoxylin-eosin (HE) staining of the femoral region in mice of the sham-operated group, the ovariectomy group (OVX), and the ovariectomy group treated with Obeticholic acid (OCA: 5 mg/kg/day; i.g; for 4 weeks).

  • 1/16

    Obeticholic acid purchased from MedChemExpress. Usage Cited in: Cell Stem Cell. 2022 Sep 1;29(9):1366-1381.e9. [Abstract]

    Customer Validation
     Mice treated with DSS for 7 days, followed by 3 days of drinking water treatment and treatment with either a carrier or Obeticholic acid (OCA: 20 mg/kg; i.g), resulted in weight loss.

  • 1/16

    Obeticholic acid purchased from MedChemExpress. Usage Cited in: Cell Stem Cell. 2022 Sep 1;29(9):1366-1381.e9. [Abstract]

    Customer Validation
     Mice were treated with DSS for 7 days, followed by 3 days of drinking water treatment and treatment with either a carrier or Obeticholic acid (OCA: 20 mg/kg; i.g). Representative H&E, PAS, and alicin blue staining were performed on intestinal sections.

  • 1/16

    Obeticholic acid purchased from MedChemExpress. Usage Cited in: Cell Stem Cell. 2022 Sep 1;29(9):1366-1381.e9. [Abstract]

    Customer Validation
     Mice were treated with DSS for 7 days, followed by 3 days of drinking water treatment and treatment with either a vector or Obeticholic acid (OCA: 20 mg/kg; i.g). The mRNA levels of the specified genes in the intestine were measured.

  • 1/16

    Obeticholic acid purchased from MedChemExpress. Usage Cited in: Cell Host Microbe. 2018 Sep 12;24(3):353-363.e5. [Abstract]

    Customer Validation
     WT cMSCs were cultured in DMEM with vehicle alone; with vehicle plus 100 ng/ml Pam3CSK4 and with Pam3CSK4 and indicated doses of agonists for FXR Obeticholic acid (INT-747: 10, 100 nM; 24 h).

  • 1/16

    Obeticholic acid purchased from MedChemExpress. Usage Cited in: J Am Soc Nephrol. 2018 Nov;29(11):2658-2670. [Abstract]

    Customer Validation
     Western blots show that INT747 (10、30 µM; 6 h) upregulate AQP2 protein expression.

  • Obeticholic acid