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PX-12

(Synonyms: IV-2)
13 Cited Publications
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Based on 13 publication(s) in Google Scholar

PX-12(IV-2) is an irreversible inhibitor of Thioredoxin-1 (Trx-1); inhibits the growth of MCF-7 and HT-29 cells with IC50 values of 1.9 and 2.9 μM, respectively.

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  • Pureté: 99.96%
  • CAS No.: 141400-58-0
  • Formule: C7H12N2S2
  • Masse moléculaire:188.31
  • Stockage:
    Powder   -20°C, 3 years , 4°C, 2 years ; In solvent   -80°C, 2 years , -20°C, 1 year
  • PX-12 Chemical Structure
    PX-12 Chemical Structure
  • Experimental Validation Results for PX-12
  • Experimental Validation Results for PX-12
  • Experimental Validation Results for PX-12
  • Experimental Validation Results for PX-12
  • Experimental Validation Results for PX-12
CAS No.: 141400-58-0
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  • PX-12 Chemical Structure
    PX-12 Chemical Structure
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  • 1/16

    PX-12 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Sep 2;16(1):8181. [Abstract]

    Customer Validation
     Cell viability in PC9 and A549 cells treated with 10 μM auranofin, PX-12, or conoidin A combined with or without DFO (100 μM) or Fer-1 (10 μM) for 24 h.

  • 1/16

    PX-12 purchased from MedChemExpress. Usage Cited in: Free Radic Biol Med. 2024 Jun:218:132-148. [Abstract]

    Customer Validation
     The BEAS-2B cells were pre-treated with DMSO or LPS (1 μg/ml) and then exposed to hydrogen (60%) with or without PX-12 (8 μM) for another 12 h (n = 3). Representative immunofluorescence images of staining for Trx1 (red), COXIV (green), and DAPI (blue) in BEAS-2B cells in different groups (n = 3) were shown. The results showed that adding PX-12 inhibited Trx1 expression. Scale bars, 10 μm.

  • 1/16

    PX-12 purchased from MedChemExpress. Usage Cited in: Free Radic Biol Med. 2024 Jun:218:132-148. [Abstract]

    Customer Validation
     Mice were pre-treated with saline or LPS (10 mg/kg; i.p.) before inhalation of air or hydrogen (4%; i.p.) with or without PX-12 (12 mg/kg; i.p.) for another 12 h. Hematoxylin and eosin staining was used to evaluate the lung histopathology (n = 5). The results showed that PX-12 reversed the protective effect of hydrogen against LPS-induced pulmonary inflammation by inhibiting Trx1, indicating that the protective action of hydrogen was related to the Trx1 pathway.

  • 1/16

    PX-12 purchased from MedChemExpress. Usage Cited in: Free Radic Biol Med. 2024 Jun:218:132-148. [Abstract]

    Customer Validation
     Mice were pre-treated with saline or LPS (10 mg/kg; i.p.) before inhalation of air or hydrogen (4%; i.p.) with or without PX-12 (12 mg/kg; i.p.) for another 12 h. Protein blots of occludin, ZO-1 and cleaved caspase-3 were detected by Western blot (n = 3). The results showed that PX-12 reversed the ameliorative effect of hydrogen on LPS-induced epithelial barrier damage in mice by inhibiting Trx1.

  • 1/16

    PX-12 purchased from MedChemExpress. Usage Cited in: J Biol Chem. 2017 Jun 2;292(22):9136-9149. [Abstract]

    Customer Validation
     The plate clone formation of SW480 and SW620 cells with Gemcitabine (8 nM in SW480 and 16 nM in SW620) and/or PX-12 (4 μM in SW480 and 8 μM in SW620).

  • PX-12