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Polydatin

(Synonyms: Piceid)
16 Cited Publications
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Based on 16 publication(s) in Google Scholar

Polydatin (Piceid), extracted from the roots of Reynoutria japonica, a widely used traditional Chinese remedies, possesses anti-inflammatory activity in several experimental models. Polydatin (Piceid) inhibits G6PD and induces oxidative and ER stresses.

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  • Pureté: 99.50%
  • CAS No.: 27208-80-6
  • Formule: C20H22O8
  • Masse moléculaire:390.38
  • Stockage:
    Powder   -20°C, 3 years , 4°C, 2 years ; In solvent   -80°C, 6 months , -20°C, 1 month
  • Polydatin Chemical Structure
    Polydatin Chemical Structure
  • Experimental Validation Results for Polydatin
  • Experimental Validation Results for Polydatin
  • Experimental Validation Results for Polydatin
  • Experimental Validation Results for Polydatin
  • Experimental Validation Results for Polydatin
  • Experimental Validation Results for Polydatin
  • Experimental Validation Results for Polydatin
CAS No.: 27208-80-6
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Cell Proliferation/Viability AssayFlow CytometryIFWBIn Vivo Efficacy Study
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  • Flow Cytometry
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  • Polydatin Chemical Structure
    Polydatin Chemical Structure
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    Polydatin purchased from MedChemExpress. Usage Cited in: Int J Mol Sci. 2023 May 5;24(9):8265. [Abstract]

    Customer Validation
     MDA-MB-231 cells and SUM159 cells were treated with BRU (20 nM) alone or in combination with Polydatin (100 nM) for 24, 48 and 72 h, and then the cell viability was determined by the CCK-8 method.

  • 1/16

    Polydatin purchased from MedChemExpress. Usage Cited in: Int J Mol Sci. 2023 May 5;24(9):8265. [Abstract]

    Customer Validation
     After treating MDA-MB-231 cells with BRU (20 nM) and Polydatin (100 nM) alone or in combination for 0, 24, 48, and 72 h, Flow cytometer was used to detect the changes in the number of cell proliferation granules of each group in the same volume (400 μL/tube) of cell solution.

  • 1/16

    Polydatin purchased from MedChemExpress. Usage Cited in: Int J Mol Sci. 2023 May 5;24(9):8265. [Abstract]

    Customer Validation
     Flow cytometer was used to detect the intracellular ROS levels change by fluorescent indicator H2DCFH-DA after treatment of cells with BRU (20 nM) and Polydatin (100 nM) for 24 h.

  • 1/16

    Polydatin purchased from MedChemExpress. Usage Cited in: Int J Mol Sci. 2023 May 5;24(9):8265. [Abstract]

    Customer Validation
     The GFP-Nrf2 plasmid was transfected into MDA-MB-231 cells. After the plasmid was expressed for 12 h, it was treated with or without H2O2 100 μM for 4–6 h. Then it was treated with 20 nM BRU alone or in combination with 100 nM Polydatin for 24 h, immunofluorescence staining and observation was performed.

  • 1/16

    Polydatin purchased from MedChemExpress. Usage Cited in: Int J Mol Sci. 2023 May 5;24(9):8265. [Abstract]

    Customer Validation
     MDA-MB-231 cells were treated with indicated concentrations of BRU or Polydatin for 24 h and total proteins were extracted for Western blot analysis.

  • 1/16

    Polydatin purchased from MedChemExpress. Usage Cited in: Int J Mol Sci. 2023 May 5;24(9):8265. [Abstract]

    Customer Validation
     Inhibition of transplanted tumor growth in vivo by BRU and Polydatin alone or in combination. BALB/c (female, 5 weeks old) were divided into three groups (n = 6) and subcutaneously injected with 5 × 106 cells; tumor volume and mice weight were measured every 7 days and administered by i.p., while the control group received i.p. of PBS (containing 1% DMSO); Mice in the vehicle alone group were injected intraperitoneally with Polydatin 50 mg/kg; The combination group received Polydatin 25 mg/kg and BRU 1 mg/kg. Schematic diagram of administration mode and treatment cycle of nude mice. The blue arrow indicates the starting date of subcutaneous tumor transplantation in mice and the dissection and analysis of the transplanted tumor on the 64th day. The red arrow indicates the position representing the time and frequency of each administration.

  • 1/16

    Polydatin purchased from MedChemExpress. Usage Cited in: ACS Chem Neurosci. 2023 Mar 1;14(5):977-987. [Abstract]

    Customer Validation
     Polydatin (PD; 100 mg/kg/day; p.o.) inhibits hippocampal inflammation through NFκB signaling in mice. CUMS: chronic unpredictable mild stress.

  • Polydatin