Cat. No.: HY-113498

Sphingomyelin

1 Cited Publications

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Sphingomyelin is a eukaryotic sphingolipid and one of the major constituents of cell membranes and particularly abundant in the myelin sheath that surrounds neuronal axons. Sphingomyelin plays an important role in cell processes, the regulation of inflammatory responses, and signal transduction. Sphingomyelin metabolism is associated with various central nervous system diseases and Niemann–Pick disease.

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Pureté: 98.0%
CAS No.: 85187-10-6

Stockage:

Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month

Sphingomyelin Chemical Structure

CAS No.: 85187-10-6

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Publications Citing Use of MedChemExpress (MCE) Sphingomyelin

Microbiol Spectr. 2025 Feb 11:e0221724. [Abstract]

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Histological Imaging/StainingIn Vivo Efficacy Study

Histological Imaging/Staining
In Vivo Efficacy Study

Activité biologique
- Description
- IC₅₀ & Target
- In Vitro
- Essai clinique
Chemical Information
Publications (1)
Solvant et solubilité
- In Vitro
- In Vivo
Pureté et documentation
Références
Calculators
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Classifications
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Description

IC₅₀ & Target

Human Endogenous Metabolite

Microbial Metabolite

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In Vitro

Sphingomyelin metabolism resulting in the production of various interconvertible bioactive sphingolipids or derivatives such as ceramide, diacylglyceride, and sphingosine-1-phosphate. These bioactive lipids act on their specific targets within the cell and regulate various signal transduction pathways, thereby affecting cellular functions^[1].
Sphingomyelin enriched lipid raft mediated cell signaling^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Essai clinique

NCT Number	Sponsor	Condition	Start Date	Phase A549
NCT01329991	Plexxikon\|		2011-05	PHASE1

Chemical Information

CAS No. 85187-10-6
Appearance Solid
Color White to off-white
SMILES

[Sphingomyelin]
Structure Classification
- Ketones, Aldehydes, Acids
Initial Source
- Endogenous metabolite
Livraison

Room temperature in continental US; may vary elsewhere.

Stockage

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

Publications (1)

All Histological Imaging/StainingIn Vivo Efficacy Study

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Microbiol Spectr

Effects of azithromycin on alleviating airway inflammation in asthmatic mice by regulating airway microbiota and metabolites. [Abstract]

2025 Feb 11:e0221724. PMID: 39932326

Sphingomyelin purchased from MedChemExpress. Usage Cited in: Microbiol Spectr. 2025 Feb 11:e0221724. [Abstract]

Sphingomyelin (SM) significantly reduced inflammatory cell infiltration in the airways of HDM-induced asthmatic mice.

Sphingomyelin purchased from MedChemExpress. Usage Cited in: Microbiol Spectr. 2025 Feb 11:e0221724. [Abstract]

(C) BALF total cell count and BALF eosinophilia percentage among groups. (D) BALF IL-4, IL-5, and IL-13 levels among groups. The results showed that compared with the HDM group, Sphingomyelin (SM) administration will alleviate airway inflammation in mice, manifested by lower total cell counts, EOS percentage, and T2 cytokines.

Solvant et solubilité

In Vitro:

Ethanol : 25 mg/mL (Need ultrasonic)

View the Complete Stock Solution Preparation Table

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

Stock Solution Working Solution

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% EtOH 90% (20% SBE-β-CD in Saline)

Solubility: 1.67 mg/mL; Suspended solution; Need ultrasonic

This protocol yields a suspended solution of 1.67 mg/mL. Suspended solution can be used for oral and intraperitoneal injection.

Taking 1 mL working solution as an example, add 100 μL EtOH stock solution (16.7 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

Protocol 2

Add each solvent one by one: 10% EtOH 90% Corn Oil

Solubility: ≥ 1.67 mg/mL; Clear solution

This protocol yields a clear solution of ≥ 1.67 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Taking 1 mL working solution as an example, add 100 μL EtOH stock solution (16.7 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Working solution concentration: 0.22 mg/mL

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (270 KB)
SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Chakraborty M, et al. Sphingomyelin and its role in cellular signaling. Adv Exp Med Biol. 2013;991:1-14. [Content Brief]

[2]. Schneider N, et al. Sphingomyelin in Brain and Cognitive Development: Preliminary Data. eNeuro. 2019 Aug 6;6(4). pii: ENEURO.0421-18.2019. [Content Brief]

[3]. Bienias K, et al. Regulation of sphingomyelin metabolism. Pharmacol Rep. 2016 Jun;68(3):570-81. [Content Brief]

[4]. Schuchman EH, et al. Types A and B Niemann-Pick disease. Mol Genet Metab. 2017 Jan - Feb;120(1-2):27-33. [Content Brief]

Calculators

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Calculateur de dilution

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

Sphingomyelin

1 Cited Publications

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Sphingomyelin

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Publications Citing Use of MedChemExpress (MCE) Sphingomyelin

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Publications (1)

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Références

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Help & FAQs

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