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Cat. No.: HY-179119

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AB19

AB19 is a potent Vav1 inhibitor. AB19 inhibits Vav1 and reduces its downstream ERK phosphorylation. AB19 shows anti-proliferative activity in pancreatic cancer models. AB19 can be used for pancreatic cancer research.

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Formule: C₂₈H₄₆BrNO₄
Masse moléculaire:540.57

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (263 KB)

AB19 Chemical Structure

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- In Vitro
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
Bioz

Activité biologique

Description

Voir tous les produits spécifiques à Isoform ERK :

In Vitro

AB19 (0-1 μM, 4 days) exhibits antitumoral activity in Vav1 positive pancreatic cancer lines, including CAPAN-2, MIA PaCa-2, and CFPAC cells^[1].
AB19 (0.1-1 μM) reduces Vav1 expression and inhibits ERK phosphorylation in CAPAN-2 cells^[1].
AB19 (0-1 μM, 5 days) exhibits antitumoral activity in pancreatic cancer patient-derived organoids (PDOs), showing greater potency in Vav1 high-expressing HO219 compared to the low-expressing HO163 model^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[1]

Cell Line:

CAPAN-2, MIA PaCa-2, CFPAC, ASPC-1, and HPNE cells
Concentration:

0, 0.1, and 1 μM
Incubation Time:

4 days
Result:

Showed a reduction in Vav1 positive cell (CAPAN-2, MIA PaCa-2, and CFPAC) numbers relative to the control at 1 μM.
Showed no effect on Vav1 negative ASPC-1 and HPNE cells.

Chemical Information

Masse moléculaire 540.57
Formule C₂₈H₄₆BrNO₄
SMILES

CCCCCCCCCCCCCC[N+]1=CC=C(OCC(C/C2=C(C)\C)(CO)OC2=O)C=C1.[Br-]
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (263 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Bellomo A, et al. Novel DAG-Lactone-Based Vav1 Inhibitors Show Anti-proliferative Activity in Pancreatic Cancer Models. ChemMedChem. 2025 Oct 20:e202500589. [Content Brief]

Calculators

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Molecular Weight Molecular Weight

Calculateur de dilution

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Activité biologique
- Description
- In Vitro
Chemical Information
Pureté et documentation
Références

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AB19

Voir tous les produits spécifiques à Isoform ERK

Activité biologique

Chemical Information

Pureté et documentation

Références

Calculators

Help & FAQs

AB19 Related Classifications

HY-179119 Related Classifications