ABBV-3373
Based on 1 Customer Validation
ABBV-3373 is an anti-TNF antibody-drug conjugate (ADC). ABBV-3373 consists of a humanized TNF antibody Adalimumab (HY-P9908) conjugated to a glucocorticoid receptor agonist (HY-148436). ABBV-3373 can be used for the research of rheumatoid arthritis.
Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.
- Pureté: 98.78%
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Stockage:
-80°C, protect from light
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
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Activité biologique
The ABBV-3373 surrogate (3-10 mg/kg; single administration) inhibits FITC-induced ear swelling by 55-88% in the Mus musculus contact hypersensitivity model, with minimal effects on systemic glucocorticoid biomarkers[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:DBA/1 (collagen-induced arthritis model)[1]
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Dosage:10 mg/kg (DAR4 ADC)
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Administration:i.p.; single dose
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Result:Achieved 98% inhibition of paw swelling AUC.
Maintained paw swelling reduction for > 30 days post-dose.
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Animal Model:unspecified[1]
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Dosage:10 mg/kg; 3 mg/kg
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Administration:single dose (prior to sensitization)
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Result:Inhibited ear swelling by 88%, plasma corticosterone by 15%, and plasma P1NP by 19% (at 10 mg/kg).
Inhibited ear swelling by 55%, plasma corticosterone by 6%, and caused a -16% change (increase) in plasma P1NP (at 3 mg/kg).
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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Appearance Liquid
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Color Colorless to light yellow
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SMILES
[ABBV-3373]
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Livraison
Shipping with dry ice.
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Stockage
-80°C, protect from light
Pureté et documentation
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Fiche technique (270 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Instruction de manipulation (2659 KB)
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
ABBV-3373 Related Classifications
HY-164894 Related Classifications
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