BCH001
Based on 1 Customer Validation
BCH001, a quinoline derivative, is a specific PAPD5 inhibitor. BCH001 restores telomerase activity and telomere length in dyskeratosis congenita (DC) induced pluripotent stem cells. BCH001 shows no inhibition of poly(A)-specific ribonuclease (PARN) or several other canonical and non-canonical polynucleotide polymerases. BCH001 is used to regulate aging.
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- Pureté: 98.72%
- CAS No.: 384859-58-9
- Formule: C20H15F3N2O5
- Masse moléculaire:420.34
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Stockage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Activité biologique
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Chemical Information
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Solvant et solubilité
- Pureté et documentation
- Références
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Help & FAQs
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Activité biologique
BCH001 (100 nM-1 μM; for 7 days) reduces telomerase RNA component (TERC) RNA oligo-adenylation and increases steady state TERC RNA levels in PARN-mutant iPSC clones. BCH001 causes few transcriptome-wide changes and rescues other ncRNAs disrupted by PARN mutations[1].
BCH001 (1 μM, 24-72 h) has no adverse impact on cell growth, cell cycle, or apoptosis in induced pluripotent stem cells (iPSCs) from DC[1].
BCH001 inhibits ATP- and dose-dependently recombinant PAPD5 (rPAPD5) in vitro. PAPD5 is a non-canonical polymerase that oligoadenylates and destabilizes telomerase RNA component (TERC)[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 384859-58-9
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Appearance Solid
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Masse moléculaire 420.34
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Formule C20H15F3N2O5
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Color White to yellow
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SMILES
O=C(C1=C(NC2=CC=CC=C2C(O)=O)C3=CC(OC(F)(F)F)=CC=C3N=C1)OCC
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year
Solvant et solubilité
DMSO : 125 mg/mL (297.38 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pureté et documentation
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Fiche technique (273 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Instruction de manipulation (2659 KB)
Références
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.3790 mL | 11.8951 mL | 23.7903 mL | 59.4757 mL |
| 5 mM | 0.4758 mL | 2.3790 mL | 4.7581 mL | 11.8951 mL | |
| 10 mM | 0.2379 mL | 1.1895 mL | 2.3790 mL | 5.9476 mL | |
| 15 mM | 0.1586 mL | 0.7930 mL | 1.5860 mL | 3.9650 mL | |
| 20 mM | 0.1190 mL | 0.5948 mL | 1.1895 mL | 2.9738 mL | |
| 25 mM | 0.0952 mL | 0.4758 mL | 0.9516 mL | 2.3790 mL | |
| 30 mM | 0.0793 mL | 0.3965 mL | 0.7930 mL | 1.9825 mL | |
| 40 mM | 0.0595 mL | 0.2974 mL | 0.5948 mL | 1.4869 mL | |
| 50 mM | 0.0476 mL | 0.2379 mL | 0.4758 mL | 1.1895 mL | |
| 60 mM | 0.0397 mL | 0.1983 mL | 0.3965 mL | 0.9913 mL | |
| 80 mM | 0.0297 mL | 0.1487 mL | 0.2974 mL | 0.7434 mL | |
| 100 mM | 0.0238 mL | 0.1190 mL | 0.2379 mL | 0.5948 mL |
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