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Cat. No.: HY-128061

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CDIBA

CDIBA is a cytosolic phospholipase A2 (cPLA2) inhibitor. CDIBA inhibits the activation of cPLA2 in rat diaphragm tissue. CDIBA reduces the level of mitochondrial reactive oxygen species in rat diaphragm tissue after prolonged mechanical ventilation. CDIBA attenuates protein degradation, muscle atrophy and decreased muscle strength in the diaphragm of rats after prolonged mechanical ventilation. CDIBA can be used in studies related to ventilator-induced diaphragmatic dysfunction.

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CAS No.: 479422-22-5
Formule: C₃₁H₂₆ClNO₃
Masse moléculaire:496.00

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Please store the product under the recommended conditions in the Certificate of Analysis.

CDIBA Chemical Structure

CAS No.: 479422-22-5

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Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- Cellular Effect
- In Vivo
Chemical Information
Pureté et documentation
Références
Calculators
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Activité biologique

Description

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Cellular Effect

Cell Line	Type	Value	Description	References
MC9	Inhibition	-8 % Compound: 25	Inhibition of PGF2-alpha production in the presence of exogenous arachidonic acid in MC9 cell at 1.5 uM Inhibition of PGF2-alpha production in the presence of exogenous arachidonic acid in MC9 cell at 1.5 uM	[PMID: 16392799]
MC9	Inhibition	81 % Compound: 25	Inhibition of PGF2-alpha production in MC9 cells at 1.5 uM Inhibition of PGF2-alpha production in MC9 cells at 1.5 uM	[PMID: 16392799]
MC9	Inhibition	96 % Compound: 25	Inhibition of LTB4 production in MC9 cells at 1.5 uM Inhibition of LTB4 production in MC9 cells at 1.5 uM	[PMID: 16392799]

In Vivo

CDIBA (30 mg/kg; i.p.; single injection at ventilation onset; 5 mg/kg/h; i.v.; continuous infusion; 12 hours) attenuates ventilator-induced diaphragm dysfunction in rats by reducing cPLA2 activation, mitochondrial ROS production, calpain activity, muscle atrophy, and improving diaphragm contractile force^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Wistar rats (adult male, SPF level, 450-550 g, ventilator-induced diaphragm dysfunction model)^[1]
Dosage:

30 mg/kg (i.p. injection); 5 mg/kg/h (continuous i.v. infusion)
Administration:

i.p. (single injection at ventilation onset); i.v. (continuous infusion; 12 hours)
Result:

Significantly reduced cPLA2 activation in the diaphragm.
Decreased mitochondrial H₂O₂ production in the diaphragm.
Downregulated diaphragm calpain activity.
Reduced the expression of atrophy-related genes Atrogin-1 and MuRF-1 in the diaphragm.
Increased the cross-sectional area of slow-twitch and fast-twitch diaphragm muscle fibers.
Improved diaphragm contractile function, including increased maximal tetanic forces, elevated force-frequency curve responses, and enhanced fatigue tolerance, compared to untreated ventilated rats.

Chemical Information

CAS No. 479422-22-5
Masse moléculaire 496.00
Formule C₃₁H₂₆ClNO₃
SMILES

O=C(O)C1=CC=C(OCCC=2C=3C=C(Cl)C=CC3N(C2C)C(C=4C=CC=CC4)C=5C=CC=CC5)C=C1
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Instruction de manipulation (2659 KB)

Références

[1]. Zhou XL, et al. Interactions between Cytosolic Phospholipase A2 Activation and Mitochondrial Reactive Oxygen Species Production in the Development of Ventilator-Induced Diaphragm Dysfunction. Oxid Med Cell Longev. 2019;2019:2561929. Published 2019 Apr 18. [Content Brief]

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How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Activité biologique
- Description
- In Vivo
Chemical Information
Pureté et documentation
Références

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CDIBA

Voir tous les produits spécifiques à Isoform Phospholipase