PRT3645
PRT3645 (Example 20) is a CDK Inhibitor. CDK-IN-12 Inhibits CDK4/6 with IC50 values less than 20 nM.
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- CAS No.: 2789680-97-1
- Formule: C26H29FN6OS
- Masse moléculaire:492.61
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Protocole
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
Description
IC50 & Target
[1]|
CDK4 <20 nM (IC50) |
CDK6 <20 nM (IC50) |
Essai clinique
| NCT Number | Sponsor | Condition | Start Date |
Phase
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|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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CAS No. 2789680-97-1
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Masse moléculaire 492.61
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Formule C26H29FN6OS
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SMILES
O=C1C2=C(C3(CCCC3)N1C)SC(C4=C(F)C=NC(NC5=NC=C(C6CCN(CC6)C)C=C5)=N4)=C2
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocole
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Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
PRT3645 Related Classifications
HY-153336 Related Classifications
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