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Cat. No.: HY-P99605

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Biologically Validated

Cinrebafusp alfa

(Synonyms: PRS 343)

Avis client

Based on 1 Customer Validation

Cinrebafusp alfa (PRS 343) is a high affinity CD137/HER2 bispecfic anticalin-based drug. Cinrebafusp alfa binds to recombinant human HER2 (K_d=0.3 nM) and human monomeric CD137 (4-1BB; K_d=5 nM). Cinrebafusp alfa facilitates T-cell costimulation by tumor-localized, HER2-dependent 4-1BB clustering and activation, further enhancing T-cell receptor-mediated activity and leading to tumor destruction. Cinrebafusp alfa has the potential for HER2+ solid tumors research.

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Pureté: 98.53%
CAS No.: 2218515-90-1
Masse moléculaire:187.87 kDa

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Cinrebafusp alfa Chemical Structure

CAS No.: 2218515-90-1

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Use of MCE Products

Antibody-Drug Conjugates

One-stop solution for XDC (ADC/PDC/RDC/ApDC/FDC/ISAC/VDC/SMDC)

Activité biologique
- Description
- Isotype
- Recommend Isotype Controls
- IC₅₀ & Target
- In Vitro
- In Vivo
- Essai clinique
- Conjugated
- Reconsititution
- Format
- Application
- Verified Bioactivity
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
Bioz

Activité biologique

Description

Isotype

Human IgG4 kappa

Recommend Isotype Controls

Human IgG4 (S228P) kappa, Isotype Control

IC₅₀ & Target^[1]

4-1BB

5 nM (Kd)

HER2

0.3 nM (Kd)

Voir tous les produits spécifiques à Isoform EGFR :

Voir tous les produits spécifiques à Isoform TNF Receptor :

In Vitro

Cinrebafusp alfa (PRS 343) binds HER2-expressing MCF-7 cells with an EC₅₀ of 7.4 nmol/L and binds to CHO cells transfected with human 4-1BB with an EC₅₀ of 6.2 nmol/L in a FACS assay^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Cinrebafusp alfa (PRS 343; 0.2-10 mg/kg; IV; once weekly; for 20 day) leads to tumor growth inhibition and has a dose-dependent increase of tumor-infiltrating lymphocytes in a humanized mouse model engrafted with HER2-positive SK-OV-3 tumor cells^[1].
Cinrebafusp alfa (10 mg/kg; IV; single dose) has the terminal elimination half-life of >14 days in male CD-1 mice. Cinrebafusp alfa (3 mg/kg; IV; single dose) has the terminal elimination half-life approximately 4 days in male cynomolgus monkeys^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

SK-OV-3 ovarian cancer model in human PBMC-reconstituted NOG female mice, ages 5-7 weeks^[1]
Dosage:

0.2, 1, 5, 10 mg/kg
Administration:

IV; once weekly; for 20 day
Result:

Displayed dose-dependent antitumor efficacy with doses ranging from 4 μg to 100 μg (approximately 0.2 mg/kg to 5 mg/kg), while the 200-μg dose (approximately 10 mg/kg) did not further enhance tumor regression.
Led to a significant increase in human CD45+ lymphocytes in tumor tissue.

Animal Model:

Male CD-1 mice^[1]
Dosage:

10 mg/kg (Pharmacokinetic Analysis)
Administration:

IV; single dose
Result:

Had the terminal elimination half-life of >14 days.

Essai clinique

NCT Number	Sponsor	Condition	Start Date	Phase A549
NCT01329991	Plexxikon\|		2011-05	PHASE1

Conjugated

Unconjugated

Reconsititution

The product can be reconstituted/diluted with sterile PBS or saline.

Format

Human IgG4 kappa

Application

ELISA, FACS, Functional assay

Verified Bioactivity

Immobilized Cinrebafusp alfa can bind Human 4-1BB/CD137 Protein (ECD, His Tag). The EC₅₀ for this effect is 1.33 ng/mL.
Immobilized Cinrebafusp alfa can bind Human Her2/ERBB2 Protein (ECD, His Tag). The EC₅₀ for this effect is 1.66 ng/mL.

Chemical Information

CAS No. 2218515-90-1
Appearance Liquid
Masse moléculaire 187.87 kDa
Color Colorless to light yellow
SMILES

[Cinrebafusp alfa]
Synonyms

PRS 343
Livraison

Shipping with dry ice.
Formulation

Please refer to the lot-specific COA for specific buffer information.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (262 KB)
SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Inhibitory Antibodies User Guide (603 KB)

Références

[1]. Marlon J Hinner, et al. Tumor-Localized Costimulatory T-Cell Engagement by the 4-1BB/HER2 Bispecific Antibody-Anticalin Fusion PRS-343. Clin Cancer Res. 2019 Oct 1;25(19):5878-5889. [Content Brief]

[2]. G. Ku, et al. 525O A phase I dose escalation study of PRS-343, a HER2/4-1BB bispecific molecule, in patients with HER2-positive malignancies. ABSTRACT ONLY, VOLUME 31, SUPPLEMENT 4, S462-S463, SEPTEMBER 01, 2020.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

100 mg

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Activité biologique
- Description
- Isotype
- Recommend Isotype Controls
- IC₅₀ & Target
- In Vitro
- In Vivo
- Essai clinique
- Conjugated
- Reconsititution
- Format
- Application
- Biological Activity
Chemical Information
Pureté et documentation
Références

1/16

Human IgG4 kappa
1/16

Immobilized Cinrebafusp alfa can bind Human 4-1BB/CD137 Protein (ECD, His Tag). The EC₅₀ for this effect is 1.33 ng/mL.
1/16

Immobilized Cinrebafusp alfa can bind Human Her2/ERBB2 Protein (ECD, His Tag). The EC₅₀ for this effect is 1.66 ng/mL.
1/16

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Cinrebafusp alfa

Cell-ATP Viability Detection Kit

Protein A Agarose

HOLO Human Interleukin-2 (IL-2) Detection Kit

Bradford Protein Assay Kit

DPBS Buffer (1×)

Cytotoxicity LDH Assay Kit

PBS Buffer (1×)

Antibody Inhibitor Library

Voir tous les produits spécifiques à Isoform EGFR

Voir tous les produits spécifiques à Isoform TNF Receptor

Activité biologique

Chemical Information

Pureté et documentation

Références

Calculators

Help & FAQs

Cinrebafusp alfa Related Classifications

HY-P99605 Related Classifications