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Cat. No.: HY-P11422

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CKS9

CKS9 is an M cell-targeting polypeptide with the amino acid sequence CKSTHPLSC, forming a 9-mer peptide via cyclization through a disulfide bond between the two cysteine residues. CKS9 is obtained through phage display technology screening and has high affinity for M cells. CKS9 can promote chitosan nanoparticles to cross M cells and enter the follicle-associated epithelium (FAE) of intestinal Peyer's patches (PP). CKS9 can be used in studies related to swine dysentery and oral delivery.

Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.

Formule: C₃₉H₆₄N₁₂O₁₃S₂
Masse moléculaire:973.13

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

CKS9 Chemical Structure

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Amount: USD 0.00

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- In Vitro
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
Bioz

Activité biologique

Description

In Vitro

CKS9 can be successfully grafted onto stearic acid esterified starch to form SES@CKS9-1 and SES@CKS9-2^[1].
CKS9-modified SES exhibits stronger binding affinity to integrin α5β1 than unmodified SES. CKS9 mediates key hydrogen-bond interactions at the interface of the βI/β-propeller domain of integrin, suggesting that integrin α5β1 is a potential M cell receptor for CKS9^[1].
CKS9 is conjugated with WSC via EDC/NHS, with a molar ratio of 6.37 mol%^[2].
As the C-terminal component of a computationally designed multi-epitope oral vaccine against *Helicobacter pylori*, CKS9 targets intestinal epithelial microfold cells to enhance the intestinal barrier uptake of the vaccine^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

Masse moléculaire 973.13
Formule C₃₉H₆₄N₁₂O₁₃S₂
Sequence

Cys-Lys-Ser-Thr-His-Pro-Leu-Ser-Cys (Disulfide bridge:Cys1-Cys9)
Sequence Shortening

CKSTHPLSC (Disulfide bridge:Cys1-Cys9)
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (260 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Wang T, et al. Development of M cell-targeting starch-based nanomicelles for oral delivery of immunoactive peptides[J]. Industrial Crops and Products, 2022, 184: 115074.

[2]. Jiang T, et al. Targeted oral delivery of BmpB vaccine using porous PLGA microparticles coated with M cell homing peptide-coupled chitosan. Biomaterials. 2014 Feb;35(7):2365-73. [Content Brief]

[3]. Urrutia-Baca VH, et al. Immunoinformatics Approach to Design a Novel Epitope-Based Oral Vaccine Against Helicobacter pylori. J Comput Biol. 2019 Oct;26(10):1177-1190.

Calculators

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculateur de dilution

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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