Colchiceine
Based on 1 Customer Validation
Colchiceine is one of several metabolites of the anti-gout medication Colchicine (HY-16569). Colchicine is a tubulin inhibitor and a microtubule disrupting agent, and may protect rats from developing liver injury and fibrosis.
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- CAS No.: 477-27-0
- Formule: C21H23NO6
- Masse moléculaire:385.41
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Stockage:
4°C, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| A549 | IC50 |
0.002 μg/mL
Compound: 1
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In vitro cytotoxic activity against human lung carcinoma (A549) tumor cell line
In vitro cytotoxic activity against human lung carcinoma (A549) tumor cell line
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[PMID: 15582446] |
Chemical Information
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CAS No. 477-27-0
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Appearance Solid
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Masse moléculaire 385.41
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Formule C21H23NO6
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Color Off-white to light yellow
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SMILES
CC(N[C@H](C1=C2)CCC3=CC(OC)=C(OC)C(OC)=C3C1=CC=C(O)C2=O)=O
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Synonyms
O10-Demethylcolchicine
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Structure Classification
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Initial Source
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
4°C, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
Pureté et documentation
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Fiche technique (276 KB)
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SDS (477 KB)
- English - EN (477 KB)
- Français - FR (477 KB)
- Deutsch - DE (477 KB)
- Norwegian - NO (477 KB)
- Español - ES (477 KB)
- Swedish - SV (477 KB)
- Italian - IT (477 KB)
- Korean - KR (477 KB)
- Portuguese - PT (477 KB)
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Instruction de manipulation (2659 KB)
Références
[1]. Rodríguez L, et al. Effects of colchicine and colchiceine in a biochemical model of liver injury and fibrosis. Arch Med Res. 1998;29(2):109-116. [Content Brief]
[2]. Nava-Ocampo AA, et al. Effect of colchiceine and ursodeoxycholic acid on hepatocyte and erythrocyte membranes and liver histology in experimentally induced carbon tetrachloride cirrhosis in rats. Eur J Clin Invest. 1997;27(1):77-84. [Content Brief]
[3]. Edström A, et al. Inhibition of fast axonal transport and microtubule polymerization in vitro by colchicine and colchiceine. Acta Physiol Scand. 1979;107(3):233-237. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Colchiceine Related Classifications
HY-127166 Related Classifications
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