Dalazatide TFA
Based on 1 Customer Validation
Dalazatide (ShK-186) TFA is a specific Kv1.3 potassium channel peptide inhibitor. Dalazatide TFA can be used in the study of autoimmune diseases such as multiple sclerosis (MS), lupus erythematosus, psoriasis, rheumatoid arthritis, type 1 diabetes and inflammatory bowel disease.
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- Pureté: 99.92%
- Formule: C184H296N57O55PS7.xC2HF3O2
- Masse moléculaire:4442.10 (free acid)
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Stockage:
Sealed storage, away from moisture.
Powder -80°C, 2 years , -20°C, 1 year* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
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Activité biologique
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Chemical Information
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Solvant et solubilité
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
Kv1.3[1]
Dalazatide (ShK-186) (0-1000 pM) TFA blocks the Kv1.3 current in the Ova-specific GFP+ effector memory T (Tem) cells in a dose-dependent manner with a Kd of 65 ± 5 pM[3].
Dalazatide (0-100 nM; 3 days) TFA inhibits CCR7− T cell proliferation in a dose-dependent manner[3].
Dalazatide (100 nM; 30 min) TFA immobilizes effector memory T (Tem) cells at inflammatory sites by suppressing calcium signaling and thereby preventing β1 integrin activation[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:CCR7− T cell[3]
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Concentration:0-100 nM
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Incubation Time:3 days
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Result:Inhibited cell proliferation with an IC50 of 180 ± 37 pM.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Lewis rats rats, delayed-type hypersensitivity (DTH) model[3]
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Dosage:100 μg/kg
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Administration:Subcutaneous injection, once
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Result:Reduced DTH at all time points compared to rats given saline injections. Suppressed the proliferation of the Tem cells.
Chemical Information
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Appearance Solid
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Masse moléculaire 4442.10 (free acid)
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Formule C184H296N57O55PS7.xC2HF3O2
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Color White to off-white
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Synonyms
ShK-186 TFA
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Sequence
H-{pY}-{AEEA}-Arg-Ser-Cys-Ile-Asp-Thr-Ile-Pro-Lys-Ser-Arg-Cys-Thr-Ala-Phe-Gln-Cys-Lys-His-Ser-Met-Lys-Tyr-Arg-Leu-Ser-Phe-Cys-Arg-Lys-Thr-Cys-Gly-Thr-Cys-NH2 (disulfide bridge:Cys5-Cys37,Cys14-Cys30,Cys19-Cys34)
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Sequence Shortening
H-{pY}-{AEEA}-RSCIDTIPKSRCTAFQCKHSMKYRLSFCRKTCGTC-NH2 (disulfide bridge:Cys5-Cys37,Cys14-Cys30,Cys19-Cys34)
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Sealed storage, away from moisture
Powder -80°C 2 years -20°C 1 year * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvant et solubilité
DMSO : ≥ 100 mg/mL
H2O : 100 mg/mL (Need ultrasonic)
* "≥" means soluble, but saturation unknown.
Pureté et documentation
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Fiche technique (298 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Instruction de manipulation (2659 KB)
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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