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DNL-919 (Human IgG1)

(Synonyms: TAK-920)
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Based on 1 Customer Validation

DNL-919 (TAK-920) is a human IgG1 monoclonal antibody (mAb) targeting TREM-2. DNL-919 can be used in Alzheimer's disease research. Recommended isotype control: Human IgG1 kappa, Isotype Control (HY-P99001).

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  • Pureté: 96.17%
  • Masse moléculaire:145.24 kDa
  • Stockage:

    Please store the product under the recommended conditions in the Certificate of Analysis.

  • Experimental Validation Results for DNL-919 (Human IgG1)
  • Experimental Validation Results for DNL-919 (Human IgG1)
  • DNL-919 (Human IgG1) Chemical Structure
    DNL-919 (Human IgG1) Chemical Structure
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DNL-919 (Human IgG1) Product Recommendations:

To place orders, for customer services and technical support, please contact:

609-228-6898
[email protected] [email protected]
Trouvez votre distributeur local Your local distributor: Hycultec GmbHHycultec
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  • 1/16

    Flow Cytometry analysis of THP-1 cells labelling TREM-2 (red) with DNL-919 (HY-P991442). Cells were fixed with 4% paraformaldehyde and permeabilised with 90% methanol. Then cells were stained with the primary antibody at 1/200 dilution for an hour at 4℃. Goat Anti-Human IgG H&L (AF488) (HY-P83776) was used as the secondary antibody at 1/1,000 dilution for 30 minutes at 4℃. Human IgG1 kappa (HY-P99001, blue) was used as the isotype control, cells without incubation with primary antibody were used as the unlabeled control (black).

  • 1/16

    Immobilized huTREM2-ECD-hFc-Biotin can bind DNL-919. The EC50 for this effect is 8.925 ng/mL.

  • DNL-919 (Human IgG1) Chemical Structure
    1/16
  • DNL-919 (Human IgG1)
  • Flow Cytometry analysis of THP-1 cells labelling TREM-2 (red) with DNL-919 (HY-P991442). Cells were fixed with 4% paraformaldehyde and permeabilised with 90% methanol. Then cells were stained with the primary antibody at 1/200 dilution for an hour at 4℃. Goat Anti-Human IgG H&L (AF488) (HY-P83776) was used as the secondary antibody at 1/1,000 dilution for 30 minutes at 4℃. Human IgG1 kappa (HY-P99001, blue) was used as the isotype control, cells without incubation with primary antibody were used as the unlabeled control (black).
  • Immobilized huTREM2-ECD-hFc-Biotin can bind DNL-919. The EC50 for this effect is 8.925 ng/mL.